Human Gene AKT3 (uc001iab.2)
  Description: Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3), transcript variant 1, mRNA.
RefSeq Summary (NM_005465): The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:243,663,021-244,006,584 Size: 343,564 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr1:243,668,551-244,006,472 Size: 337,922 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviews
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:243,663,021-244,006,584)mRNA (may differ from genome)Protein (479 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
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MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AKT3_HUMAN
DESCRIPTION: RecName: Full=RAC-gamma serine/threonine-protein kinase; EC=2.7.11.1; AltName: Full=Protein kinase Akt-3; AltName: Full=Protein kinase B gamma; Short=PKB gamma; AltName: Full=RAC-PK-gamma; AltName: Full=STK-2;
FUNCTION: AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser- 472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=87.9 uM for ATP (for purified and in vitro activated AKT3); KM=12.4 uM for peptide substrate (for purified and in vitro activated AKT3); KM=118.7 uM for ATP (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells); KM=2.3 uM for peptide substrate (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells);
SUBUNIT: Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
TISSUE SPECIFICITY: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
DOMAIN: Binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
PTM: Phosphorylation on Thr-305 and Ser-472 is required for full activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
PTM: Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
PTM: O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1 (By similarity).
DISEASE: Note=AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3 increases progressively during melanoma tumor progression with highest levels present in advanced-stage metastatic melanomas. Promotes melanoma tumorigenesis by decreasing apoptosis. Plays a key role in the genesis of ovarian cancers through modulation of G2/M phase transition. With AKT2, plays a pivotal role in the biology of glioblastoma.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 protein kinase domain.
CAUTION: In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though it appears to be predominantly expressed in brain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/AKT3ID615ch1q44.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): AKT3
CDC HuGE Published Literature: AKT3
Positive Disease Associations: Electrocardiography , Glucose , Hematocrit , Hemoglobin A, Glycosylated , Hemoglobins , RR interval (heart rate)
Related Studies:
  1. Electrocardiography
    Fabio Marroni et al. Circulation. Cardiovascular genetics 2009, A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project., Circulation. Cardiovascular genetics. [PubMed 20031603]
    Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
  2. Glucose
    , , . [PubMed 0]
  3. Hematocrit
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: AKT3
Diseases sorted by gene-association score: megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2* (1331), hemimegalencephaly* (367), megalencephaly-capillary malformation-polymicrogyria syndrome, somatic* (283), mpph syndrome* (202), thymoma (25), megalencephaly (22), glioma (20), glioblastoma (19), glioblastoma multiforme (16), hydrocephalus (10), hypomelanosis of ito (9), corneal fleck dystrophy (8), proteus syndrome, somatic (8), melanoma (7), corpus callosum agenesis (5), hypoparathyroidism-deafness-renal disease syndrome (5), epileptic encephalopathy, early infantile, 15 (4), heterotopia, periventricular (4), muenke syndrome (4), lennox-gastaut syndrome (3), prostate cancer (1), congenital nervous system abnormality (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.63 RPKM in Artery - Tibial
Total median expression: 427.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.00112-0.232 Picture PostScript Text
3' UTR -1569.635530-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000961 - AGC-kinase_C
IPR011009 - Kinase-like_dom
IPR011993 - PH_like_dom
IPR017892 - Pkinase_C
IPR001849 - Pleckstrin_homology
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF00169 - PH domain
PF00433 - Protein kinase C terminal domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like

SCOP Domains:
50729 - PH domain-like
56112 - Protein kinase-like (PK-like)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2X18 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9Y243
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein Sequence Protein Sequence  
 Alignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000002 mitochondrial genome maintenance
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0032008 positive regulation of TOR signaling
GO:0035556 intracellular signal transduction
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045793 positive regulation of cell size
GO:0048854 brain morphogenesis
GO:0048873 homeostasis of number of cells within a tissue
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1905653 positive regulation of artery morphogenesis
GO:2000773 negative regulation of cellular senescence

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF383661 - JP 2014500723-A/191164: Polycomb-Associated Non-Coding RNAs.
AY005799 - Homo sapiens protein kinase B gamma 1 (AKT3) mRNA, complete cds, alternatively spliced.
FW400657 - NUCLEIC ACID COMPOUNDS FOR INHIBITING AKT GENE EXPRESSION AND USES THEREOF.
LF385478 - JP 2014500723-A/192981: Polycomb-Associated Non-Coding RNAs.
BC121154 - Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), mRNA (cDNA clone MGC:150492 IMAGE:40121374), complete cds.
AL117525 - Homo sapiens mRNA; cDNA DKFZp434N0250 (from clone DKFZp434N0250).
LF205481 - JP 2014500723-A/12984: Polycomb-Associated Non-Coding RNAs.
KJ898135 - Synthetic construct Homo sapiens clone ccsbBroadEn_07529 AKT3 gene, encodes complete protein.
AB463341 - Synthetic construct DNA, clone: pF1KB8397, Homo sapiens AKT3 gene for v-akt murine thymoma viral oncogene homolog 3, without stop codon, in Flexi system.
AM392791 - Synthetic construct Homo sapiens clone IMAGE:100002102 for hypothetical protein (AKT3 gene).
AM392849 - Synthetic construct Homo sapiens clone IMAGE:100001651 for hypothetical protein (AKT3 gene).
FW400656 - NUCLEIC ACID COMPOUNDS FOR INHIBITING AKT GENE EXPRESSION AND USES THEREOF.
AF135794 - Homo sapiens AKT3 protein kinase mRNA, complete cds.
AF124141 - Homo sapiens protein kinase B gamma mRNA, complete cds.
AF085234 - Homo sapiens STK-2 mRNA, complete cds.
AK308052 - Homo sapiens cDNA, FLJ98000.
AJ245709 - Homo sapiens mRNA for serine/threonine kinase Akt-3 (Akt3 gene).
BC020479 - Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), mRNA (cDNA clone IMAGE:3867931), partial cds.
MA619238 - JP 2018138019-A/191164: Polycomb-Associated Non-Coding RNAs.
MA621055 - JP 2018138019-A/192981: Polycomb-Associated Non-Coding RNAs.
MA441058 - JP 2018138019-A/12984: Polycomb-Associated Non-Coding RNAs.
U79271 - Human clones 23920 and 23921 mRNA sequence.
LF320908 - JP 2014500723-A/128411: Polycomb-Associated Non-Coding RNAs.
LF320909 - JP 2014500723-A/128412: Polycomb-Associated Non-Coding RNAs.
AL080074 - Homo sapiens mRNA; cDNA DKFZp564B0262 (from clone DKFZp564B0262).
AK055109 - Homo sapiens cDNA FLJ30547 fis, clone BRAWH2001439.
BC019085 - Homo sapiens cDNA clone IMAGE:4870417, partial cds.
LF320910 - JP 2014500723-A/128413: Polycomb-Associated Non-Coding RNAs.
LF320911 - JP 2014500723-A/128414: Polycomb-Associated Non-Coding RNAs.
JD357007 - Sequence 338031 from Patent EP1572962.
JD190059 - Sequence 171083 from Patent EP1572962.
JD211684 - Sequence 192708 from Patent EP1572962.
JD377231 - Sequence 358255 from Patent EP1572962.
JD378452 - Sequence 359476 from Patent EP1572962.
JD524983 - Sequence 506007 from Patent EP1572962.
JD378451 - Sequence 359475 from Patent EP1572962.
JD295578 - Sequence 276602 from Patent EP1572962.
JD300746 - Sequence 281770 from Patent EP1572962.
JD110152 - Sequence 91176 from Patent EP1572962.
JD163825 - Sequence 144849 from Patent EP1572962.
JD228886 - Sequence 209910 from Patent EP1572962.
DJ444891 - Combinatorial Methods and Compositions for Treatment of Melanoma.
DJ444896 - Combinatorial Methods and Compositions for Treatment of Melanoma.
DJ444889 - Combinatorial Methods and Compositions for Treatment of Melanoma.
LF320915 - JP 2014500723-A/128418: Polycomb-Associated Non-Coding RNAs.
LF320918 - JP 2014500723-A/128421: Polycomb-Associated Non-Coding RNAs.
DJ444887 - Combinatorial Methods and Compositions for Treatment of Melanoma.
MA556485 - JP 2018138019-A/128411: Polycomb-Associated Non-Coding RNAs.
MA556486 - JP 2018138019-A/128412: Polycomb-Associated Non-Coding RNAs.
MA556487 - JP 2018138019-A/128413: Polycomb-Associated Non-Coding RNAs.
MA556488 - JP 2018138019-A/128414: Polycomb-Associated Non-Coding RNAs.
MA556492 - JP 2018138019-A/128418: Polycomb-Associated Non-Coding RNAs.
MA556495 - JP 2018138019-A/128421: Polycomb-Associated Non-Coding RNAs.
LF320919 - JP 2014500723-A/128422: Polycomb-Associated Non-Coding RNAs.
LF320920 - JP 2014500723-A/128423: Polycomb-Associated Non-Coding RNAs.
KJ452457 - Homo sapiens PVT1/AKT3 fusion protein isoform 2 mRNA, partial cds.
LF320923 - JP 2014500723-A/128426: Polycomb-Associated Non-Coding RNAs.
MA556496 - JP 2018138019-A/128422: Polycomb-Associated Non-Coding RNAs.
MA556497 - JP 2018138019-A/128423: Polycomb-Associated Non-Coding RNAs.
MA556500 - JP 2018138019-A/128426: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04150 - mTOR signaling pathway
hsa04210 - Apoptosis
hsa04370 - VEGF signaling pathway
hsa04510 - Focal adhesion
hsa04530 - Tight junction
hsa04620 - Toll-like receptor signaling pathway
hsa04630 - Jak-STAT signaling pathway
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04722 - Neurotrophin signaling pathway
hsa04910 - Insulin signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa04920 - Adipocytokine signaling pathway
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05211 - Renal cell carcinoma
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05218 - Melanoma
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

Reactome (by CSHL, EBI, and GO)

Protein Q9Y243 (Reactome details) participates in the following event(s):

R-HSA-198284 PIP3 recruits PDK1 and AKT to the membrane
R-HSA-2317332 PIP3 recruits AKT to the membrane
R-HSA-390329 Dephosphorylation of AKT by PP2A
R-HSA-198298 AKT translocates to the nucleus
R-HSA-199425 PHLPP dephosphorylates S473 in AKT
R-HSA-198270 PDPK1 phosphorylates AKT at T308
R-HSA-198640 TORC2 (mTOR) phosphorylates AKT at S473
R-HSA-199443 THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
R-HSA-2400010 AKT inhibitors block AKT membrane recruitment
R-HSA-2317314 AKT binds PDPK1
R-HSA-199298 AKT phosphorylates CREB1
R-HSA-199299 AKT can phosphorylate forkhead box transcription factors
R-HSA-199839 AKT can phosphorylate RSK
R-HSA-199863 AKT can phosphorylate NR4A1 (NUR77)
R-HSA-211164 AKT phosphorylates FOXO1A
R-HSA-6805640 AKT phosphorylates KAT6A
R-HSA-6805785 AKT phosphorylates PHF20
R-HSA-8939963 Activated AKT phosphorylates RUNX2
R-HSA-198347 AKT phosphorylates BAD
R-HSA-198371 AKT phosphorylates GSK3
R-HSA-198599 AKT phosphorylates MDM2
R-HSA-198609 AKT phosphorylates TSC2, inhibiting it
R-HSA-198611 AKT phosphorylates IKKalpha
R-HSA-198613 AKT phosphorylates p21Cip1 and p27Kip1
R-HSA-198621 AKT phosphorylates caspase-9
R-HSA-200143 AKT phosphorylates AKT1S1 (PRAS40)
R-HSA-389756 AKT interacts and phosphorylates Cot
R-HSA-1358791 Phosphorylation of USP8 by P-AKT
R-NUL-3139045 AKT phosphorylates Bad
R-HSA-8933446 Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
R-HSA-8948757 AKT phosphorylates MKRN1
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-397795 G-protein beta:gamma signalling
R-HSA-389356 CD28 co-stimulation
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-388841 Costimulation by the CD28 family
R-HSA-198693 AKT phosphorylates targets in the nucleus
R-HSA-211163 AKT-mediated inactivation of FOXO1A
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
R-HSA-8941332 RUNX2 regulates genes involved in cell migration
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-198323 AKT phosphorylates targets in the cytosol
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-388396 GPCR downstream signalling
R-HSA-162582 Signal Transduction
R-HSA-1280218 Adaptive Immune System
R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-194138 Signaling by VEGF
R-HSA-114452 Activation of BH3-only proteins
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-69206 G1/S Transition
R-HSA-69242 S Phase
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9007101 Rab regulation of trafficking
R-HSA-6807070 PTEN Regulation
R-HSA-5663202 Diseases of signal transduction
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-186712 Regulation of beta-cell development
R-HSA-212436 Generic Transcription Pathway
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1227986 Signaling by ERBB2
R-HSA-199991 Membrane Trafficking
R-HSA-1643685 Disease
R-HSA-1266738 Developmental Biology
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-109581 Apoptosis
R-HSA-1640170 Cell Cycle
R-HSA-5653656 Vesicle-mediated transport
R-HSA-74160 Gene expression (Transcription)
R-HSA-5357801 Programmed Cell Death

-  Other Names for This Gene
  Alternate Gene Symbols: AKT3_HUMAN, NM_005465, NP_005456, PKBG, Q0VAA6, Q5VTI1, Q5VTI2, Q96QV3, Q9UFP5, Q9Y243
UCSC ID: uc001iab.2
RefSeq Accession: NM_005465
Protein: Q9Y243 (aka AKT3_HUMAN)
CCDS: CCDS31077.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene AKT3:
mpph (MPPH Syndrome)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_005465.4
exon count: 13CDS single in 3' UTR: no RNA size: 7091
ORF size: 1440CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3080.00frame shift in genome: no % Coverage: 99.87
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 18# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.