Human Gene ALPK2 (uc002lhj.4)
  Description: Homo sapiens alpha-kinase 2 (ALPK2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr18:56,148,482-56,296,189 Size: 147,708 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr18:56,149,055-56,279,029 Size: 129,975 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:56,148,482-56,296,189)mRNA (may differ from genome)Protein (2170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ALPK2_HUMAN
DESCRIPTION: RecName: Full=Alpha-protein kinase 2; EC=2.7.11.-; AltName: Full=Heart alpha-protein kinase;
FUNCTION: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.
SIMILARITY: Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
SIMILARITY: Contains 1 alpha-type protein kinase domain.
SIMILARITY: Contains 2 Ig-like (immunoglobulin-like) domains.
SEQUENCE CAUTION: Sequence=AAK95952.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK95952.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC03812.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03812.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BX647796; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAD89922.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ALPK2
CDC HuGE Published Literature: ALPK2

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.68 RPKM in Heart - Atrial Appendage
Total median expression: 70.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.40214-0.250 Picture PostScript Text
3' UTR -161.19573-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR011009 - Kinase-like_dom
IPR004166 - MHCK_EF2_kinase

Pfam Domains:
PF02816 - Alpha-kinase family
PF07679 - Immunoglobulin I-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q86TB3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AY044450 - Homo sapiens heart alpha-kinase (HAK) mRNA, complete cds.
BX647796 - Homo sapiens mRNA; cDNA DKFZp686G2187 (from clone DKFZp686G2187).
AL832018 - Homo sapiens mRNA; cDNA DKFZp451G074 (from clone DKFZp451G074); complete cds.
BX647639 - Homo sapiens mRNA; cDNA DKFZp451J236 (from clone DKFZp451J236).
BC172418 - Synthetic construct Homo sapiens clone IMAGE:100069112, MGC:199123 alpha-kinase 2 (ALPK2) mRNA, encodes complete protein.
AK092133 - Homo sapiens cDNA FLJ34814 fis, clone NT2NE2007727.
AX747371 - Sequence 896 from Patent EP1308459.
BX647446 - Homo sapiens mRNA; cDNA DKFZp451C077 (from clone DKFZp451C077).
JD554556 - Sequence 535580 from Patent EP1572962.
JD180795 - Sequence 161819 from Patent EP1572962.
JD522569 - Sequence 503593 from Patent EP1572962.
JD534358 - Sequence 515382 from Patent EP1572962.
JD409925 - Sequence 390949 from Patent EP1572962.
JD410224 - Sequence 391248 from Patent EP1572962.
JD509329 - Sequence 490353 from Patent EP1572962.
JD189053 - Sequence 170077 from Patent EP1572962.
AK092194 - Homo sapiens cDNA FLJ34875 fis, clone NT2NE2015262.
AX747403 - Sequence 928 from Patent EP1308459.
AK125243 - Homo sapiens cDNA FLJ43253 fis, clone HEART2007031.
JD037813 - Sequence 18837 from Patent EP1572962.
JD062628 - Sequence 43652 from Patent EP1572962.
JD103416 - Sequence 84440 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ALPK2_HUMAN, HAK, NM_052947, NP_443179, Q6ZUX0, Q86TB3, Q8NAT5, Q96L95
UCSC ID: uc002lhj.4
RefSeq Accession: NM_052947
Protein: Q86TB3 (aka ALPK2_HUMAN)
CCDS: CCDS11966.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_052947.3
exon count: 13CDS single in 3' UTR: no RNA size: 7303
ORF size: 6513CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 12714.50frame shift in genome: no % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.