Description: Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), mRNA. RefSeq Summary (NM_212481): Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr2:97,202,464-97,218,371 Size: 15,908 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr2:97,202,564-97,218,050 Size: 15,487 Coding Exon Count: 7
ID:ARI5A_HUMAN DESCRIPTION: RecName: Full=AT-rich interactive domain-containing protein 5A; Short=ARID domain-containing protein 5A; AltName: Full=Modulator recognition factor 1; Short=MRF-1; FUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer- dependent gene expressison. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 ARID domain. SEQUENCE CAUTION: Sequence=AAA36325.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q03989
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003714 transcription corepressor activity GO:0003723 RNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0030331 estrogen receptor binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046965 retinoid X receptor binding GO:0046966 thyroid hormone receptor binding GO:0050681 androgen receptor binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002376 immune system process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045087 innate immune response GO:0045892 negative regulation of transcription, DNA-templated GO:0071391 cellular response to estrogen stimulus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
