Description: Homo sapiens CD69 molecule (CD69), mRNA. RefSeq Summary (NM_001781): This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr12:9,905,082-9,913,497 Size: 8,416 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr12:9,906,077-9,913,416 Size: 7,340 Coding Exon Count: 5
ID:CD69_HUMAN DESCRIPTION: RecName: Full=Early activation antigen CD69; AltName: Full=Activation inducer molecule; Short=AIM; AltName: Full=BL-AC/P26; AltName: Full=C-type lectin domain family 2 member C; AltName: Full=EA1; AltName: Full=Early T-cell activation antigen p60; AltName: Full=GP32/28; AltName: Full=Leukocyte surface antigen Leu-23; AltName: Full=MLR-3; AltName: CD_antigen=CD69; FUNCTION: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. DEVELOPMENTAL STAGE: Earliest inducible cell surface glycoprotein acquired during lymphoid activation. INDUCTION: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells. PTM: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=CD69; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_235";
Diabetes Mellitus, Type 1 Jeffrey C Barrett et al. Nature genetics 2009, Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes., Nature genetics.
[PubMed 19430480]
type 1 diabetes Barrett ,et al. 2009, Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes, Nature genetics 2009 .
[PubMed 19430480]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q07108
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
