Description: Homo sapiens cholinergic receptor, nicotinic, alpha 9 (neuronal) (CHRNA9), mRNA. RefSeq Summary (NM_017581): This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]. Transcript (Including UTRs) Position: hg19 chr4:40,337,346-40,357,234 Size: 19,889 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr4:40,337,485-40,356,537 Size: 19,053 Coding Exon Count: 5
ID:ACHA9_HUMAN DESCRIPTION: RecName: Full=Neuronal acetylcholine receptor subunit alpha-9; AltName: Full=Nicotinic acetylcholine receptor subunit alpha-9; Short=NACHR alpha-9; Flags: Precursor; FUNCTION: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion. SUBUNIT: Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers. SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells. MISCELLANEOUS: The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist). SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 9/CHRNA9 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UGM1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005262 calcium channel activity GO:0005515 protein binding GO:0015276 ligand-gated ion channel activity GO:0022848 acetylcholine-gated cation-selective channel activity
Biological Process: GO:0006811 ion transport GO:0006812 cation transport GO:0006816 calcium ion transport GO:0007165 signal transduction GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007605 sensory perception of sound GO:0034220 ion transmembrane transport GO:0042472 inner ear morphogenesis GO:0050910 detection of mechanical stimulus involved in sensory perception of sound GO:0060078 regulation of postsynaptic membrane potential GO:0060079 excitatory postsynaptic potential GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0070588 calcium ion transmembrane transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
