Human Gene CYC1 (uc003zaz.4)
  Description: Homo sapiens cytochrome c-1 (CYC1), nuclear gene encoding mitochondrial protein, mRNA.
RefSeq Summary (NM_001916): This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013].
Transcript (Including UTRs)
   Position: hg19 chr8:145,149,960-145,152,428 Size: 2,469 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr8:145,150,003-145,152,239 Size: 2,237 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:145,149,960-145,152,428)mRNA (may differ from genome)Protein (325 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CYC1
CDC HuGE Published Literature: CYC1

-  MalaCards Disease Associations
  MalaCards Gene Search: CYC1
Diseases sorted by gene-association score: mitochondrial complex iii deficiency, nuclear type 6* (1219), mitochondrial respiratory chain complex iii deficiency, cyc1-related* (500), mitochondrial complex iii deficiency* (159), contagious pustular dermatitis (11)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 228.19 RPKM in Heart - Left Ventricle
Total median expression: 3942.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.2043-0.353 Picture PostScript Text
3' UTR -71.80189-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002326 - Cyt_c1
IPR021157 - Cyt_c1_TM_anchor_C
IPR009056 - Cyt_c_dom

Pfam Domains:
PF02167 - Cytochrome C1 family

SCOP Domains:
46626 - Cytochrome c
81496 - Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor

ModBase Predicted Comparative 3D Structure on Q8TBT6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0009055 electron carrier activity
GO:0020037 heme binding

Biological Process:
GO:0022900 electron transport chain


-  Descriptions from all associated GenBank mRNAs
  LF210324 - JP 2014500723-A/17827: Polycomb-Associated Non-Coding RNAs.
AK225796 - Homo sapiens mRNA for cytochrome c-1 variant, clone: FCC131B02.
AK026633 - Homo sapiens cDNA: FLJ22980 fis, clone KAT11387, highly similar to HSCYC1 Human mRNA for cytochrome c1.
BC001006 - Homo sapiens cytochrome c-1, mRNA (cDNA clone MGC:8481 IMAGE:2821836), complete cds.
X06994 - Human mRNA for cytochrome c1.
BC015616 - Homo sapiens cytochrome c-1, mRNA (cDNA clone MGC:23492 IMAGE:4840922), complete cds.
BC020566 - Homo sapiens cytochrome c-1, mRNA (cDNA clone MGC:21555 IMAGE:4157475), complete cds.
BT019798 - Homo sapiens cytochrome c-1 mRNA, complete cds.
DQ891486 - Synthetic construct clone IMAGE:100004116; FLH177384.01X; RZPDo839H02124D cytochrome c-1 (CYC1) gene, encodes complete protein.
DQ894671 - Synthetic construct Homo sapiens clone IMAGE:100009131; FLH177381.01L; RZPDo839H02123D cytochrome c-1 (CYC1) gene, encodes complete protein.
KJ896676 - Synthetic construct Homo sapiens clone ccsbBroadEn_06070 CYC1 gene, encodes complete protein.
CR541674 - Homo sapiens full open reading frame cDNA clone RZPDo834A0328D for gene CYC1, cytochrome c-1; complete cds, incl. stopcodon.
BC024650 - Homo sapiens, clone IMAGE:4470223, mRNA, partial cds.
JD022806 - Sequence 3830 from Patent EP1572962.
JD019717 - Sequence 741 from Patent EP1572962.
JD033511 - Sequence 14535 from Patent EP1572962.
JD033674 - Sequence 14698 from Patent EP1572962.
JD019307 - Sequence 331 from Patent EP1572962.
M16597 - Human cytochrome c1 mRNA, partial cds.
BC033076 - Homo sapiens cDNA clone IMAGE:5516956, **** WARNING: chimeric clone ****.
LF337100 - JP 2014500723-A/144603: Polycomb-Associated Non-Coding RNAs.
LF337101 - JP 2014500723-A/144604: Polycomb-Associated Non-Coding RNAs.
LF337103 - JP 2014500723-A/144606: Polycomb-Associated Non-Coding RNAs.
JD476099 - Sequence 457123 from Patent EP1572962.
LF337104 - JP 2014500723-A/144607: Polycomb-Associated Non-Coding RNAs.
JD424499 - Sequence 405523 from Patent EP1572962.
JD361385 - Sequence 342409 from Patent EP1572962.
LF337105 - JP 2014500723-A/144608: Polycomb-Associated Non-Coding RNAs.
MA445901 - JP 2018138019-A/17827: Polycomb-Associated Non-Coding RNAs.
MA572677 - JP 2018138019-A/144603: Polycomb-Associated Non-Coding RNAs.
MA572678 - JP 2018138019-A/144604: Polycomb-Associated Non-Coding RNAs.
MA572680 - JP 2018138019-A/144606: Polycomb-Associated Non-Coding RNAs.
MA572681 - JP 2018138019-A/144607: Polycomb-Associated Non-Coding RNAs.
MA572682 - JP 2018138019-A/144608: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa04260 - Cardiac muscle contraction
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

BioCyc Knowledge Library
PWY-3781 - aerobic respiration -- electron donor II

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001916, NP_001907, Q8TBT6, Q8TBT6_HUMAN
UCSC ID: uc003zaz.4
RefSeq Accession: NM_001916
Protein: Q8TBT6 CCDS: CCDS6415.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001916.3
exon count: 7CDS single in 3' UTR: no RNA size: 1235
ORF size: 978CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 2156.00frame shift in genome: no % Coverage: 97.98
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.