Human Gene EMID1 (uc003aem.4)
  Description: Homo sapiens EMI domain containing 1 (EMID1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr22:29,601,901-29,655,586 Size: 53,686 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr22:29,602,028-29,654,933 Size: 52,906 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:29,601,901-29,655,586)mRNA (may differ from genome)Protein (443 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): EMID1
CDC HuGE Published Literature: EMID1
Positive Disease Associations: Arteries
Related Studies:
  1. Arteries
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.53 RPKM in Spleen
Total median expression: 297.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.40127-0.539 Picture PostScript Text
3' UTR -310.10653-0.475 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF01391 - Collagen triple helix repeat (20 copies)
PF07546 - EMI domain

ModBase Predicted Comparative 3D Structure on Q96A84-3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC046358 - Homo sapiens EMI domain containing 1, mRNA (cDNA clone MGC:50657 IMAGE:5770546), complete cds.
CR456407 - Homo sapiens bK984G1.1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.bK984G1.1).
CU013253 - Homo sapiens EMID1, mRNA (cDNA clone IMAGE:100000031), complete cds, without stop codon, in Gateway system.
CU012965 - Homo sapiens EMID1, mRNA (cDNA clone IMAGE:100000127), complete cds, with stop codon, in Gateway system.
KJ900126 - Synthetic construct Homo sapiens clone ccsbBroadEn_09520 EMID1 gene, encodes complete protein.
AB463024 - Synthetic construct DNA, clone: pF1KB8714, Homo sapiens EMID1 gene for EMI domain containing 1, without stop codon, in Flexi system.
AJ416090 - Homo sapiens mRNA for putative emu1 protein.
AL831910 - Homo sapiens mRNA; cDNA DKFZp547H099 (from clone DKFZp547H099).
BC013830 - Homo sapiens EMI domain containing 1, mRNA (cDNA clone IMAGE:4149063).
AK097163 - Homo sapiens cDNA FLJ39844 fis, clone SPLEN2014381.
JD544634 - Sequence 525658 from Patent EP1572962.
JD210489 - Sequence 191513 from Patent EP1572962.
JD319882 - Sequence 300906 from Patent EP1572962.
JD400474 - Sequence 381498 from Patent EP1572962.
JD260405 - Sequence 241429 from Patent EP1572962.
JD175239 - Sequence 156263 from Patent EP1572962.
JD476603 - Sequence 457627 from Patent EP1572962.
JD459958 - Sequence 440982 from Patent EP1572962.
JD177306 - Sequence 158330 from Patent EP1572962.
JD107085 - Sequence 88109 from Patent EP1572962.
JD479055 - Sequence 460079 from Patent EP1572962.
JD483448 - Sequence 464472 from Patent EP1572962.
JD389702 - Sequence 370726 from Patent EP1572962.
JD151280 - Sequence 132304 from Patent EP1572962.
JD201219 - Sequence 182243 from Patent EP1572962.
JD190975 - Sequence 171999 from Patent EP1572962.
JD374662 - Sequence 355686 from Patent EP1572962.
JD458615 - Sequence 439639 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: EMU1, NM_133455, NP_597712, Q96A84-3, uc003aem.3
UCSC ID: uc003aem.4
RefSeq Accession: NM_133455
Protein: Q96A84-3, splice isoform of Q96A84 CCDS: CCDS33630.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_133455.3
exon count: 15CDS single in 3' UTR: no RNA size: 2133
ORF size: 1332CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2591.00frame shift in genome: no % Coverage: 99.02
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.