Human Gene EXOC1 (uc003hbf.1)
  Description: Homo sapiens exocyst complex component 1 (EXOC1), transcript variant 3, mRNA.
RefSeq Summary (NM_001024924): The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr4:56,719,816-56,771,244 Size: 51,429 Total Exon Count: 19 Strand: +
Coding Region
   Position: hg19 chr4:56,724,490-56,770,661 Size: 46,172 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:56,719,816-56,771,244)mRNA (may differ from genome)Protein (894 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EXOC1_HUMAN
DESCRIPTION: RecName: Full=Exocyst complex component 1; AltName: Full=Exocyst complex component Sec3;
FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.
SIMILARITY: Belongs to the SEC3 family.
SEQUENCE CAUTION: Sequence=AAF64268.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EXOC1
Diseases sorted by gene-association score: commensal bacterial infectious disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D001554 Benzene
  • C006780 bisphenol A
  • C045651 epigallocatechin gallate
  • C027373 potassium chromate(VI)
  • C025643 vinclozolin

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.34 RPKM in Esophagus - Mucosa
Total median expression: 689.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -132.60314-0.422 Picture PostScript Text
3' UTR -136.43583-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019160 - Exocyst_Exoc1

Pfam Domains:
PF09763 - Exocyst complex component Sec3
PF15277 - Exocyst complex component SEC3 N-terminal PIP2 binding PH

ModBase Predicted Comparative 3D Structure on Q9NV70
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0017049 GTP-Rho binding

Biological Process:
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016241 regulation of macroautophagy
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050714 positive regulation of protein secretion
GO:0051601 exocyst localization
GO:0051607 defense response to virus

Cellular Component:
GO:0000145 exocyst
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0090543 Flemming body
GO:0098592 cytoplasmic side of apical plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC094751 - Homo sapiens exocyst complex component 1, mRNA (cDNA clone MGC:104609 IMAGE:4828034), complete cds.
AK001755 - Homo sapiens cDNA FLJ10893 fis, clone NT2RP4002791.
AK027413 - Homo sapiens cDNA FLJ14507 fis, clone NT2RM1000399.
AB590476 - Synthetic construct DNA, clone: pFN21AE2210, Homo sapiens EXOC1 gene for exocyst complex component 1, without stop codon, in Flexi system.
KJ899188 - Synthetic construct Homo sapiens clone ccsbBroadEn_08582 EXOC1 gene, encodes complete protein.
AL833208 - Homo sapiens mRNA; cDNA DKFZp667M116 (from clone DKFZp667M116).
AK027047 - Homo sapiens cDNA: FLJ23394 fis, clone HEP17539, highly similar to AF208854 Homo sapiens BM-012 mRNA.
AF208854 - Homo sapiens BM-012 mRNA, complete cds.
BC020650 - Homo sapiens exocyst complex component 1, mRNA (cDNA clone IMAGE:4243918), partial cds.
AK023461 - Homo sapiens cDNA FLJ13399 fis, clone PLACE1001395.
BC019237 - Homo sapiens exocyst complex component 1, mRNA (cDNA clone IMAGE:3935158), partial cds.
JD534327 - Sequence 515351 from Patent EP1572962.
JD403537 - Sequence 384561 from Patent EP1572962.
JD131018 - Sequence 112042 from Patent EP1572962.
JD385521 - Sequence 366545 from Patent EP1572962.
JD166603 - Sequence 147627 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NV70 (Reactome details) participates in the following event(s):

R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex
R-HSA-264876 Insulin processing
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-2980736 Peptide hormone metabolism
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: BM-012, EXOC1_HUMAN, NM_001024924, NP_060731, Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4, SEC3, SEC3L1
UCSC ID: uc003hbf.1
RefSeq Accession: NM_001024924
Protein: Q9NV70 (aka EXOC1_HUMAN)
CCDS: CCDS3502.1, CCDS3503.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001024924.1
exon count: 19CDS single in 3' UTR: no RNA size: 3582
ORF size: 2685CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5570.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.