Description: Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 1, mRNA. RefSeq Summary (NM_001083899): This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]. Transcript (Including UTRs) Position: hg19 chr19:55,525,075-55,549,632 Size: 24,558 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr19:55,525,450-55,549,604 Size: 24,155 Coding Exon Count: 8
myocardial infarct; thrombosis, deep vein Ollikainen, E. et al. 2004, Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men., Atherosclerosis. 2004 Sep;176(1):95-9.
[PubMed 15306180]
Our findings support previous results on the role of this GPVI polymorphism, or another linked polymorphism, as a possible predictor of the risk of coronary thrombosis.
Platelet Aggregation Andrew D Johnson et al. Nature genetics 2010, Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists., Nature genetics.
[PubMed 20526338]
venous thrombosis Bezemer, I.D. et al, JAMA. 2008;299(11):1306-14, Gene variants associated with deep vein thrombosis, JAMA.
[PubMed 18349091]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCN6-3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
