Human Gene JUN (uc001cze.3)
  Description: Homo sapiens jun proto-oncogene (JUN), mRNA.
RefSeq Summary (NM_002228): This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr1:59,246,463-59,249,785 Size: 3,323 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr1:59,247,747-59,248,742 Size: 996 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:59,246,463-59,249,785)mRNA (may differ from genome)Protein (331 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: JUN_HUMAN
DESCRIPTION: RecName: Full=Transcription factor AP-1; AltName: Full=Activator protein 1; Short=AP1; AltName: Full=Proto-oncogene c-Jun; AltName: Full=V-jun avian sarcoma virus 17 oncogene homolog; AltName: Full=p39;
FUNCTION: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
SUBUNIT: Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.
INTERACTION: Q06481:APLP2; NbExp=3; IntAct=EBI-852823, EBI-79306; P05067:APP; NbExp=2; IntAct=EBI-852823, EBI-77613; P15336:ATF2; NbExp=4; IntAct=EBI-852823, EBI-1170906; Q8IWZ6:BBS7; NbExp=3; IntAct=EBI-852823, EBI-1806001; O43889:CREB3; NbExp=4; IntAct=EBI-852823, EBI-625002; P14921:ETS1; NbExp=3; IntAct=EBI-852823, EBI-913209; P01100:FOS; NbExp=6; IntAct=EBI-852823, EBI-852851; P07900:HSP90AA1; NbExp=2; IntAct=EBI-852823, EBI-296047; Q8WQG9:jnk-1 (xeno); NbExp=3; IntAct=EBI-852823, EBI-321822; P52292:KPNA2; NbExp=2; IntAct=EBI-852823, EBI-349938; P45983:MAPK8; NbExp=2; IntAct=EBI-852823, EBI-286483; P45983-1:MAPK8; NbExp=2; IntAct=EBI-852823, EBI-288687; Q9UPY8:MAPRE3; NbExp=3; IntAct=EBI-852823, EBI-726739; Q00987:MDM2; NbExp=3; IntAct=EBI-852823, EBI-389668; P48634:PRRC2A; NbExp=2; IntAct=EBI-852823, EBI-347545; Q9NRL3:STRN4; NbExp=3; IntAct=EBI-852823, EBI-717245; Q99986:VRK1; NbExp=4; IntAct=EBI-852823, EBI-1769146;
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
PTM: Acetylated at Lys-271 by EP300.
SIMILARITY: Belongs to the bZIP family. Jun subfamily.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JUNID151.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/jun/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): JUN
CDC HuGE Published Literature: JUN
Positive Disease Associations: Body Weights and Measures , Cognitive performance , Heart Failure , Psychomotor Performance
Related Studies:
  1. Body Weights and Measures
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  2. Cognitive performance
    Need ,et al. 2009, A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery, Human molecular genetics 2009 18- 23 : 4650-61. [PubMed 19734545]
  3. Heart Failure
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: JUN
Diseases sorted by gene-association score: sarcoma (18), pertussis (11), teratocarcinoma (11), esophageal adenosquamous carcinoma (10), brain sarcoma (10), status epilepticus (9), marek disease (9), campylobacteriosis (9), pyriform sinus cancer (8), hemorrhagic cystitis (8), photokeratitis (7), ocular hypertension (7), fibrosarcoma (7), small intestine neuroendocrine neoplasm (7), monocytic leukemia (7), human t-cell leukemia virus type 1 (6), chronic pain (6), krabbe disease (6), alveolar periostitis (6), meibomian cyst (6), hepatocellular carcinoma (6), colorectal cancer (6), influenza (6), embryonal carcinoma (5), toxic myocarditis (5), narcissistic personality disorder (5), atherosclerosis (5), periosteal osteogenic sarcoma (5), salmonellosis (4), hyperglycemia (4), rheumatoid arthritis (4), phencyclidine abuse (4), lung cancer (4), breast cancer (4), patellofemoral pain syndrome (4), endometrial cancer (4), microphthalmia, isolated 1 (3), renal cell carcinoma (3), nasopharyngeal carcinoma (3), osteoporosis (3), prostate cancer (2), ovarian cancer, somatic (2), esophageal cancer (2), osteosarcoma, somatic (2), leukemia, acute promyelocytic, somatic (2), leukemia, acute myeloid (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 226.02 RPKM in Adipose - Visceral (Omentum)
Total median expression: 4057.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -474.901043-0.455 Picture PostScript Text
3' UTR -386.001284-0.301 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR015558 - C_Jun
IPR008917 - Euk_TF_DNA-bd
IPR005643 - JNK
IPR002112 - Leuzip_Jun

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF03957 - Jun-like transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A02 - X-ray MuPIT 1FOS - X-ray MuPIT 1JNM - X-ray MuPIT 1JUN - NMR MuPIT 1S9K - X-ray MuPIT 1T2K - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P05412
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0033613 activating transcription factor binding
GO:0035497 cAMP response element binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0070412 R-SMAD binding
GO:0071837 HMG box domain binding

Biological Process:
GO:0001525 angiogenesis
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0003151 outflow tract morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007568 aging
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0009987 cellular process
GO:0010033 response to organic substance
GO:0010634 positive regulation of epithelial cell migration
GO:0014070 response to organic cyclic compound
GO:0030224 monocyte differentiation
GO:0031103 axon regeneration
GO:0031953 negative regulation of protein autophosphorylation
GO:0032496 response to lipopolysaccharide
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0034614 cellular response to reactive oxygen species
GO:0035026 leading edge cell differentiation
GO:0035994 response to muscle stretch
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0045597 positive regulation of cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051365 cellular response to potassium ion starvation
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0051899 membrane depolarization
GO:0060395 SMAD protein signal transduction
GO:0061029 eyelid development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071276 cellular response to cadmium ion
GO:0071277 cellular response to calcium ion
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1904707 positive regulation of vascular smooth muscle cell proliferation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:2000144 positive regulation of DNA-templated transcription, initiation

Cellular Component:
GO:0000228 nuclear chromosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
GO:0035976 transcription factor AP-1 complex


-  Descriptions from all associated GenBank mRNAs
  JD197370 - Sequence 178394 from Patent EP1572962.
JD298548 - Sequence 279572 from Patent EP1572962.
BC068522 - Homo sapiens jun oncogene, mRNA (cDNA clone MGC:87323 IMAGE:5267423), complete cds.
BC009874 - Homo sapiens jun oncogene, mRNA (cDNA clone IMAGE:3947905), partial cds.
JD356867 - Sequence 337891 from Patent EP1572962.
JD446194 - Sequence 427218 from Patent EP1572962.
JD060945 - Sequence 41969 from Patent EP1572962.
JD331196 - Sequence 312220 from Patent EP1572962.
AK307137 - Homo sapiens cDNA, FLJ97085.
JD398161 - Sequence 379185 from Patent EP1572962.
BC006175 - Homo sapiens jun oncogene, mRNA (cDNA clone MGC:13254 IMAGE:4053956), complete cds.
BC002646 - Homo sapiens jun oncogene, mRNA (cDNA clone IMAGE:3606344).
JD266269 - Sequence 247293 from Patent EP1572962.
CR541724 - Homo sapiens full open reading frame cDNA clone RZPDo834D0929D for gene JUN, v-jun sarcoma virus 17 oncogene homolog (avian); complete cds, incl. stopcodon.
KJ905219 - Synthetic construct Homo sapiens clone ccsbBroadEn_14682 JUN gene, encodes complete protein.
BT019759 - Homo sapiens v-jun sarcoma virus 17 oncogene homolog (avian) mRNA, complete cds.
DQ896432 - Synthetic construct Homo sapiens clone IMAGE:100010892; FLH194262.01L; RZPDo839H0469D v-jun sarcoma virus 17 oncogene homolog (avian) (JUN) gene, encodes complete protein.
AB385120 - Synthetic construct DNA, clone: pF1KB5556, Homo sapiens JUN gene for transcription factor AP-1, complete cds, without stop codon, in Flexi system.
CR541752 - Homo sapiens full open reading frame cDNA clone RZPDo834E1029D for gene JUN, v-jun sarcoma virus 17 oncogene homolog (avian); complete cds, without stopcodon.
DL236228 - Vascular Therapeutics.
JD106497 - Sequence 87521 from Patent EP1572962.
JD423173 - Sequence 404197 from Patent EP1572962.
JD065070 - Sequence 46094 from Patent EP1572962.
JD042591 - Sequence 23615 from Patent EP1572962.
JD382520 - Sequence 363544 from Patent EP1572962.
JD180000 - Sequence 161024 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04310 - Wnt signaling pathway
hsa04510 - Focal adhesion
hsa04620 - Toll-like receptor signaling pathway
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04722 - Neurotrophin signaling pathway
hsa04912 - GnRH signaling pathway
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection
hsa05140 - Leishmaniasis
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05211 - Renal cell carcinoma

BioCarta from NCI Cancer Genome Anatomy Project
h_41bbPathway - The 4-1BB-dependent immune response
h_bcrPathway - BCR Signaling Pathway
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_pdgfPathway - PDGF Signaling Pathway
h_agrPathway - Agrin in Postsynaptic Differentiation
h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
h_d4gdiPathway - D4-GDI Signaling Pathway
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System
h_il6Pathway - IL 6 signaling pathway
h_mapkPathway - MAPKinase Signaling Pathway
h_tcrPathway - T Cell Receptor Signaling Pathway
h_tollPathway - Toll-Like Receptor Pathway
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM
h_egfPathway - EGF Signaling Pathway
h_il1rPathway - Signal transduction through IL1R
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_tnfr1Pathway - TNFR1 Signaling Pathway
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_epoPathway - EPO Signaling Pathway
h_fasPathway - FAS signaling pathway ( CD95 )
h_insulinPathway - Insulin Signaling Pathway
h_pcafpathway - The information-processing pathway at the IFN-beta enhancer
h_tsp1Pathway - TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2
h_atmPathway - ATM Signaling Pathway
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_stressPathway - TNF/Stress Related Signaling
h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage
h_etsPathway - METS affect on Macrophage Differentiation
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_keratinocytePathway - Keratinocyte Differentiation
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_il2Pathway - IL 2 signaling pathway
h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
h_TPOPathway - TPO Signaling Pathway
h_igf1Pathway - IGF-1 Signaling Pathway
h_integrinPathway - Integrin Signaling Pathway
h_ngfPathway - Nerve growth factor pathway (NGF)

Reactome (by CSHL, EBI, and GO)

Protein P05412 (Reactome details) participates in the following event(s):

R-HSA-8868666 CDK5:p25 phosphorylates JUN
R-HSA-168440 Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
R-HSA-450292 Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
R-HSA-168136 Activated JNKs phosphorylate c-JUN
R-HSA-5692761 JUN binds MAPK6 gene
R-HSA-8944047 JUN binds the PTEN gene promoter
R-HSA-3222533 ERK1/2-activated AP1 complex binds KDM6B promoter
R-HSA-3797196 AP-1 transcription factor binds IGFBP7 promoter
R-HSA-4568737 AP-1 transcription factor binds IL1A promoter
R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-HSA-6806412 TP53 and AP-1 bind the MSH2 promoter
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-450341 Activation of the AP-1 family of transcription factors
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8863678 Neurodegenerative Diseases
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-2559583 Cellular Senescence
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5683057 MAPK family signaling cascades
R-HSA-6807070 PTEN Regulation
R-HSA-1643685 Disease
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-450294 MAP kinase activation
R-HSA-2262752 Cellular responses to stress
R-HSA-168249 Innate Immune System
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-8939211 ESR-mediated signaling
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-168256 Immune System
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-212436 Generic Transcription Pathway
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-449147 Signaling by Interleukins
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: JUN_HUMAN, NM_002228, NP_002219, P05412, Q96G93
UCSC ID: uc001cze.3
RefSeq Accession: NM_002228
Protein: P05412 (aka JUN_HUMAN)
CCDS: CCDS610.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002228.3
exon count: 1CDS single in 3' UTR: no RNA size: 3338
ORF size: 996CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 2147.00frame shift in genome: no % Coverage: 99.55
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.