Description: Homo sapiens nucleosome assembly protein 1-like 4 (NAP1L4), mRNA. RefSeq Summary (NM_005969): This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr11:2,965,660-3,013,607 Size: 47,948 Total Exon Count: 16 Strand: - Coding Region Position: hg19 chr11:2,970,489-3,000,450 Size: 29,962 Coding Exon Count: 14
ID:NP1L4_HUMAN DESCRIPTION: RecName: Full=Nucleosome assembly protein 1-like 4; AltName: Full=Nucleosome assembly protein 2; Short=NAP-2; INTERACTION: P04608:tat (xeno); NbExp=3; IntAct=EBI-2255116, EBI-6164389; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis. PTM: Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity). SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00956 - Nucleosome assembly protein (NAP)
ModBase Predicted Comparative 3D Structure on Q99733
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
