Human Gene RPS6KB2 (uc001old.3)
  Description: Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 2 (RPS6KB2), mRNA.
RefSeq Summary (NM_003952): This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015].
Transcript (Including UTRs)
   Position: hg19 chr11:67,195,935-67,202,879 Size: 6,945 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr11:67,196,017-67,202,640 Size: 6,624 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:67,195,935-67,202,879)mRNA (may differ from genome)Protein (482 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: KS6B2_HUMAN
DESCRIPTION: RecName: Full=Ribosomal protein S6 kinase beta-2; Short=S6K-beta-2; Short=S6K2; EC=2.7.11.1; AltName: Full=70 kDa ribosomal protein S6 kinase 2; Short=P70S6K2; Short=p70-S6K 2; AltName: Full=S6 kinase-related kinase; Short=SRK; AltName: Full=Serine/threonine-protein kinase 14B; AltName: Full=p70 ribosomal S6 kinase beta; Short=S6K-beta; Short=p70 S6 kinase beta; Short=p70 S6K-beta; Short=p70 S6KB; Short=p70-beta;
FUNCTION: Phosphorylates specifically ribosomal protein S6.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated and activated by MTOR.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RPS6KB2
CDC HuGE Published Literature: RPS6KB2

-  MalaCards Disease Associations
  MalaCards Gene Search: RPS6KB2
Diseases sorted by gene-association score: kleine-levin hibernation syndrome (12), recurrent hypersomnia (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 56.89 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 946.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.1082-0.416 Picture PostScript Text
3' UTR -113.60239-0.475 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000961 - AGC-kinase_C
IPR011009 - Kinase-like_dom
IPR017892 - Pkinase_C
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR016238 - Ribosomal_S6_kinase
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF00433 - Protein kinase C terminal domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9UBS0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0042277 peptide binding

Biological Process:
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
GO:0043491 protein kinase B signaling
GO:0045948 positive regulation of translational initiation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF211141 - JP 2014500723-A/18644: Polycomb-Associated Non-Coding RNAs.
BC136564 - Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 2, mRNA (cDNA clone MGC:168177 IMAGE:9020554), complete cds.
BC000094 - Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 2, mRNA (cDNA clone MGC:1848 IMAGE:3508140), complete cds.
AK297527 - Homo sapiens cDNA FLJ58914 complete cds, highly similar to Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1).
AB019245 - Homo sapiens p70 S6Kb mRNA for S6 kinase b, complete cds.
AB208827 - Homo sapiens mRNA for ribosomal protein S6 kinase, 70kDa, polypeptide 2 isoform a variant protein.
BC006106 - Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 2, mRNA (cDNA clone MGC:12950 IMAGE:2959036), complete cds.
AF099739 - Homo sapiens S6 kinase-related kinase mRNA, complete cds.
AB016869 - Homo sapiens mRNA for p70 ribosomal S6 kinase beta, complete cds.
AF076931 - Homo sapiens serine/threonine kinase 14 beta (STK14B) mRNA, complete cds.
LF344244 - JP 2014500723-A/151747: Polycomb-Associated Non-Coding RNAs.
AB529007 - Synthetic construct DNA, clone: pF1KE0954, Homo sapiens RPS6KB2 gene for ribosomal protein S6 kinase, 70kDa, polypeptide 2, without stop codon, in Flexi system.
KJ897503 - Synthetic construct Homo sapiens clone ccsbBroadEn_06897 RPS6KB2 gene, encodes complete protein.
BX538119 - Homo sapiens mRNA; cDNA DKFZp686B24218 (from clone DKFZp686B24218).
LF344243 - JP 2014500723-A/151746: Polycomb-Associated Non-Coding RNAs.
LF344242 - JP 2014500723-A/151745: Polycomb-Associated Non-Coding RNAs.
LF344241 - JP 2014500723-A/151744: Polycomb-Associated Non-Coding RNAs.
JD393642 - Sequence 374666 from Patent EP1572962.
JD109505 - Sequence 90529 from Patent EP1572962.
LF344240 - JP 2014500723-A/151743: Polycomb-Associated Non-Coding RNAs.
MA579821 - JP 2018138019-A/151747: Polycomb-Associated Non-Coding RNAs.
MA579820 - JP 2018138019-A/151746: Polycomb-Associated Non-Coding RNAs.
MA579819 - JP 2018138019-A/151745: Polycomb-Associated Non-Coding RNAs.
MA579818 - JP 2018138019-A/151744: Polycomb-Associated Non-Coding RNAs.
MA579817 - JP 2018138019-A/151743: Polycomb-Associated Non-Coding RNAs.
MA446718 - JP 2018138019-A/18644: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04150 - mTOR signaling pathway
hsa04350 - TGF-beta signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04910 - Insulin signaling pathway
hsa05221 - Acute myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_mapkPathway - MAPKinase Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein Q9UBS0 (Reactome details) participates in the following event(s):

R-HSA-199839 AKT can phosphorylate RSK
R-HSA-2399999 AKT1 E17K mutant phosphorylates RSK
R-HSA-198693 AKT phosphorylates targets in the nucleus
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-5663202 Diseases of signal transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: B2RMZ9, KS6B2_HUMAN, NM_003952, NP_003943, O94809, Q9UBS0, Q9UEC1, STK14B
UCSC ID: uc001old.3
RefSeq Accession: NM_003952
Protein: Q9UBS0 (aka KS6B2_HUMAN)
CCDS: CCDS41677.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003952.2
exon count: 15CDS single in 3' UTR: no RNA size: 1782
ORF size: 1449CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3022.00frame shift in genome: no % Coverage: 99.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.