Description: Homo sapiens sex hormone-binding globulin (SHBG), transcript variant 1, mRNA. RefSeq Summary (NM_001040): This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Transcript (Including UTRs) Position: hg19 chr17:7,533,453-7,536,700 Size: 3,248 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr17:7,533,491-7,536,670 Size: 3,180 Coding Exon Count: 8
ID:SHBG_HUMAN DESCRIPTION: RecName: Full=Sex hormone-binding globulin; Short=SHBG; AltName: Full=Sex steroid-binding protein; Short=SBP; AltName: Full=Testis-specific androgen-binding protein; Short=ABP; AltName: Full=Testosterone-estradiol-binding globulin; Short=TeBG; AltName: Full=Testosterone-estrogen-binding globulin; Flags: Precursor; FUNCTION: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity). TISSUE SPECIFICITY: Isoform 1 and isoform 2 are present in liver and testis. SIMILARITY: Contains 2 laminin G-like domains. WEB RESOURCE: Name=Wikipedia; Note=Androgen-binding protein entry; URL="http://en.wikipedia.org/wiki/Androgen-binding_protein";
bone density dihydrotestosterone estradiol sex hormone binding globulin testosterone Eriksson, A. L. et al. 2006, SHBG gene promoter polymorphisms in men are associated with serum SHBG, androgen and androgen metabolite levels and hip BMD, J Clin Endocrinol Metab 2006.
[PubMed 16926255]
Our findings demonstrate that polymorphisms in the SHBG promoter predict serum levels of SHBG, androgens, and glucuronidated androgen metabolites, and hip BMD in men.
breast cancer Cui, Y. et al. 2005, Association of breast cancer risk with a common functional polymorphism (Asp327Asn) in the sex hormone-binding globulin gene., Cancer epidemiology, biomarkers & prevention. 2005 May;14(5):1096-101.
[PubMed 15894658]
This study suggests that the Asn allele in the SHBG gene may be related to a reduced risk of breast cancer among postmenopausal women by increasing their blood SHBG levels.
endometrial cancer Kataoka, N. et al. 2007, Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene, Cancer 2007.
[PubMed 17315164]
The current results suggested that the codon 327 Asn allele in the SHBG gene may be related to a reduced risk of endometrial cancer among postmenopausal women.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04278
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
