Human Gene SRC (uc002xgy.3)
  Description: Homo sapiens v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 2, mRNA.
RefSeq Summary (NM_198291): This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr20:35,974,557-36,033,821 Size: 59,265 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr20:36,012,557-36,031,782 Size: 19,226 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:35,974,557-36,033,821)mRNA (may differ from genome)Protein (536 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SRC_HUMAN
DESCRIPTION: RecName: Full=Proto-oncogene tyrosine-protein kinase Src; EC=2.7.10.2; AltName: Full=Proto-oncogene c-Src; AltName: Full=pp60c-src; Short=p60-Src;
FUNCTION: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin- 43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr- 1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to beta- arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
ENZYME REGULATION: Phosphorylation by CSK at Tyr-530 inhibits kinase activity. Inhibitory phosphorylation at Tyr-530 is enhanced by heme. Further phosphorylation by CDK1 partially reactivates CSK-inactivated SRC and facilitates complete reactivation by protein tyrosine phosphatase PTPRC. Integrin engagement stimulates kinase activity. Phosphorylation by PTK2/FAK1 enhances kinase activity. Butein and pseudosubstrate-based peptide inhibitors like CIYKYYF act as inhibitors. Phosphorylation at Tyr-419 increases kinase activity.
SUBUNIT: Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ERBB2, STAT1 and PNN. Interacts with DDR1, DDR2 and DAB2. Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain. Interacts with CAV2 (tyrosine phosphorylated form). Interacts (via the SH3 domain and the protein kinase domain) with ARRB1; the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with ARRB1 and ARRB2. Interacts with SRCIN1. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with PIK3CA and/or PIK3C2B, PTK2/FAK1 and ESR1 (dimethylated on arginine). Interacts with FASLG. Interacts (via SH2 domain) with the 'Tyr- 402' phosphorylated form of PTK2B/PYK2. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PDGFRA (tyrosine phosphorylated). Interacts with CSF1R. Interacts (via SH2 and SH3 domain) with TNK2. Interacts (via protein kinase domin) with the tyrosine phosphorylated form of RUNX3 (via runt domain). Interacts with TRAF3 (via RING-type zinc finger domain). Interacts with DDX58, MAVS and TBK1. Interacts (via SH2 domain) with GNB2L1/RACK1; the interaction is enhanced by tyrosine phosphorylation of GNB2L1 and inhibits SRC activity. Interacts with EPHB1; activates the MAPK/ERK cascade to regulate cell migration. Interacts with FCAMR. Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with AMOTL2; this interaction regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites.
INTERACTION: P42684:ABL2; NbExp=2; IntAct=EBI-621482, EBI-1102694; P12814:ACTN1; NbExp=2; IntAct=EBI-621482, EBI-351710; Q8R5G7:Arap3 (xeno); NbExp=3; IntAct=EBI-621482, EBI-621463; Q9ULH1:ASAP1; NbExp=2; IntAct=EBI-621482, EBI-346622; P12830:CDH1; NbExp=2; IntAct=EBI-621482, EBI-727477; P00533:EGFR; NbExp=5; IntAct=EBI-621482, EBI-297353; P04626:ERBB2; NbExp=10; IntAct=EBI-621482, EBI-641062; P03372-4:ESR1; NbExp=2; IntAct=EBI-621482, EBI-4309277; P25445:FAS; NbExp=2; IntAct=EBI-621482, EBI-494743; Q9Y6K9:IKBKG; NbExp=3; IntAct=EBI-621482, EBI-81279; P35968:KDR; NbExp=2; IntAct=EBI-621482, EBI-1005487; Q07666:KHDRBS1; NbExp=3; IntAct=EBI-621482, EBI-1364; Q05397:PTK2; NbExp=4; IntAct=EBI-621482, EBI-702142; Q13905:RAPGEF1; NbExp=2; IntAct=EBI-621482, EBI-976876; Q01973:ROR1; NbExp=9; IntAct=EBI-621482, EBI-6082337; Q9C0H9:SRCIN1; NbExp=3; IntAct=EBI-621482, EBI-1393949; Q68CZ2:TNS3; NbExp=13; IntAct=EBI-621482, EBI-1220488;
SUBCELLULAR LOCATION: Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.
TISSUE SPECIFICITY: Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
DOMAIN: The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
PTM: Myristoylated at Gly-2, and this is essential for targeting to membranes.
PTM: Dephosphorylated at Tyr-530 by PTPRJ (By similarity). Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-419. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-530, the SH3 domain engaged with the SH2-kinase linker, and Tyr-419 dephosphorylated. Dephosphorylation of Tyr-530 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-530, Tyr-419 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-530 by CSK allows this interaction to reform, resulting in SRC inactivation. CDK5-mediated phosphorylation at Ser-75 targets SRC to ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. Phosphorylated by PTK2/FAK1; this enhances kinase activity. Phosphorylated by PTK2B/PYK2; this enhances kinase activity.
PTM: S-nitrosylation is important for activation of its kinase activity (By similarity).
PTM: Ubiquitinated in response to CDK5-mediated phosphorylation.
DISEASE: Note=SRC kinase activity has been shown to be increased in several tumor tissues and tumor cell lines such as colon carcinoma cells.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SH3 domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SRC
CDC HuGE Published Literature: SRC

-  MalaCards Disease Associations
  MalaCards Gene Search: SRC
Diseases sorted by gene-association score: thrombocytopenia 6* (1628), colorectal cancer* (147), sarcoma (84), cherubism (13), mucinous stomach adenocarcinoma (10), thrombocytopenia (9), agammaglobulinemia, x-linked 1 (9), gallbladder adenocarcinoma (9), wiskott-aldrich syndrome (8), ataxia, cerebellar, cayman type (8), osteopetrosis (8), differentiating neuroblastoma (8), agammaglobulinemia (7), shigellosis (7), central sleep apnea (6), protoplasmic astrocytoma (6), signet ring cell adenocarcinoma (6), cellular congenital mesoblastic nephroma (5), spherocytosis, type 1 (5), kaposi sarcoma (5), pancreatic cancer (4), breast cancer (4), retinitis pigmentosa 26 (4), cerebral primitive neuroectodermal tumor (4), cd45 deficiency (3), noonan syndrome 1 (3), leukemia, chronic myeloid, somatic (3), lung cancer (3), prostate cancer (3), pancreatic ductal adenocarcinoma (2), stomach cancer (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.23 RPKM in Prostate
Total median expression: 518.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -138.00348-0.397 Picture PostScript Text
3' UTR -878.812039-0.431 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR000980 - SH2
IPR001452 - SH3_domain
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom

Pfam Domains:
PF00017 - SH2 domain
PF00018 - SH3 domain
PF00069 - Protein kinase domain
PF07653 - Variant SH3 domain
PF07714 - Protein tyrosine kinase
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain
56112 - Protein kinase-like (PK-like)
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A07 - X-ray MuPIT 1A08 - X-ray MuPIT 1A09 - X-ray MuPIT 1A1A - X-ray MuPIT 1A1B - X-ray MuPIT 1A1C - X-ray MuPIT 1A1E - X-ray MuPIT 1FMK - X-ray MuPIT 1HCS - NMR MuPIT 1HCT - NMR MuPIT 1KSW - X-ray MuPIT 1O41 - X-ray MuPIT 1O42 - X-ray MuPIT 1O43 - X-ray MuPIT 1O44 - X-ray MuPIT 1O45 - X-ray MuPIT 1O46 - X-ray MuPIT 1O47 - X-ray MuPIT 1O48 - X-ray MuPIT 1O49 - X-ray MuPIT 1O4A - X-ray MuPIT 1O4B - X-ray MuPIT 1O4C - X-ray MuPIT 1O4D - X-ray MuPIT 1O4E - X-ray MuPIT 1O4F - X-ray MuPIT 1O4G - X-ray MuPIT 1O4H - X-ray MuPIT 1O4I - X-ray MuPIT 1O4J - X-ray MuPIT 1O4K - X-ray MuPIT 1O4L - X-ray MuPIT 1O4M - X-ray MuPIT 1O4N - X-ray MuPIT 1O4O - X-ray MuPIT 1O4P - X-ray MuPIT 1O4Q - X-ray MuPIT 1O4R - X-ray MuPIT 1SHD - X-ray MuPIT 1Y57 - X-ray MuPIT 1YI6 - X-ray MuPIT 1YOJ - X-ray MuPIT 1YOL - X-ray MuPIT 1YOM - X-ray MuPIT 2BDF - X-ray MuPIT 2BDJ - X-ray MuPIT 2H8H - X-ray MuPIT 2SRC - X-ray MuPIT 4F59 - X-ray MuPIT 4F5A - X-ray MuPIT 4F5B - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P12931
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005080 protein kinase C binding
GO:0005102 receptor binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0020037 heme binding
GO:0030331 estrogen receptor binding
GO:0031625 ubiquitin protein ligase binding
GO:0042169 SH2 domain binding
GO:0044325 ion channel binding
GO:0044877 macromolecular complex binding
GO:0045296 cadherin binding
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0050839 cell adhesion molecule binding
GO:0051219 phosphoprotein binding
GO:0051427 hormone receptor binding
GO:0070851 growth factor receptor binding
GO:0071253 connexin binding
GO:0097110 scaffold protein binding

Biological Process:
GO:0001545 primary ovarian follicle growth
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002376 immune system process
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0008283 cell proliferation
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0010447 response to acidic pH
GO:0010628 positive regulation of gene expression
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0010907 positive regulation of glucose metabolic process
GO:0010954 positive regulation of protein processing
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016032 viral process
GO:0016236 macroautophagy
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0022407 regulation of cell-cell adhesion
GO:0030168 platelet activation
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030900 forebrain development
GO:0031295 T cell costimulation
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0031954 positive regulation of protein autophosphorylation
GO:0032148 activation of protein kinase B activity
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032463 negative regulation of protein homooligomerization
GO:0032869 cellular response to insulin stimulus
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0033625 positive regulation of integrin activation
GO:0034332 adherens junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0035635 entry of bacterium into host cell
GO:0036035 osteoclast development
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043114 regulation of vascular permeability
GO:0043149 stress fiber assembly
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 regulation of protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045056 transcytosis
GO:0045087 innate immune response
GO:0045124 regulation of bone resorption
GO:0045453 bone resorption
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048477 oogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050847 progesterone receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051222 positive regulation of protein transport
GO:0051385 response to mineralocorticoid
GO:0051602 response to electrical stimulus
GO:0051726 regulation of cell cycle
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051974 negative regulation of telomerase activity
GO:0060065 uterus development
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070542 response to fatty acid
GO:0070555 response to interleukin-1
GO:0071222 cellular response to lipopolysaccharide
GO:0071375 cellular response to peptide hormone stimulus
GO:0071393 cellular response to progesterone stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071498 cellular response to fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071801 regulation of podosome assembly
GO:0071803 positive regulation of podosome assembly
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0086098 angiotensin-activated signaling pathway involved in heart process
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098609 cell-cell adhesion
GO:1900182 positive regulation of protein localization to nucleus
GO:1902533 positive regulation of intracellular signal transduction
GO:2000386 positive regulation of ovarian follicle development
GO:2000394 positive regulation of lamellipodium morphogenesis
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000641 regulation of early endosome to late endosome transport
GO:2000811 negative regulation of anoikis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001286 regulation of caveolin-mediated endocytosis

Cellular Component:
GO:0002102 podosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032587 ruffle membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AF272982 - Homo sapiens SRC tyrosine kinase mRNA, partial sequence, alternatively spliced.
Z18364 - H.sapiens 5' non-coding end of the c-Src proto-oncogene.
BC051270 - Homo sapiens v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian), mRNA (cDNA clone MGC:59921 IMAGE:4871614), complete cds.
BC011566 - Homo sapiens v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian), mRNA (cDNA clone MGC:20184 IMAGE:4548399), complete cds.
JD196787 - Sequence 177811 from Patent EP1572962.
JF432365 - Synthetic construct Homo sapiens clone IMAGE:100073560 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC) gene, encodes complete protein.
KJ897598 - Synthetic construct Homo sapiens clone ccsbBroadEn_06992 SRC gene, encodes complete protein.
EU831426 - Synthetic construct Homo sapiens clone HAIB:100066455; DKFZo008C0117 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) protein (SRC) gene, encodes complete protein.
EU831519 - Synthetic construct Homo sapiens clone HAIB:100066548; DKFZo004C0118 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) protein (SRC) gene, encodes complete protein.
AB529215 - Synthetic construct DNA, clone: pF1KB9961, Homo sapiens SRC gene for v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog, without stop codon, in Flexi system.
CU679964 - Synthetic construct Homo sapiens gateway clone IMAGE:100020718 5' read SRC mRNA.
AK024281 - Homo sapiens cDNA FLJ14219 fis, clone NT2RP3003800, highly similar to Rattus norvegicus tyrosine protein kinase pp60-c-src mRNA.
AK091756 - Homo sapiens cDNA FLJ34437 fis, clone HLUNG2001126, moderately similar to TYROSINE-PROTEIN KINASE SRC-1 (EC 2.7.1.112).
AX747164 - Sequence 689 from Patent EP1308459.
JD104668 - Sequence 85692 from Patent EP1572962.
JD211371 - Sequence 192395 from Patent EP1572962.
JD056375 - Sequence 37399 from Patent EP1572962.
JD395272 - Sequence 376296 from Patent EP1572962.
JD274073 - Sequence 255097 from Patent EP1572962.
JD201600 - Sequence 182624 from Patent EP1572962.
JD190632 - Sequence 171656 from Patent EP1572962.
JD452267 - Sequence 433291 from Patent EP1572962.
JD100527 - Sequence 81551 from Patent EP1572962.
JD057298 - Sequence 38322 from Patent EP1572962.
JD406366 - Sequence 387390 from Patent EP1572962.
JD193274 - Sequence 174298 from Patent EP1572962.
JD132695 - Sequence 113719 from Patent EP1572962.
JD540675 - Sequence 521699 from Patent EP1572962.
JD544873 - Sequence 525897 from Patent EP1572962.
JD476344 - Sequence 457368 from Patent EP1572962.
JD414332 - Sequence 395356 from Patent EP1572962.
JD325077 - Sequence 306101 from Patent EP1572962.
JD139477 - Sequence 120501 from Patent EP1572962.
JD216633 - Sequence 197657 from Patent EP1572962.
JD191242 - Sequence 172266 from Patent EP1572962.
JD389898 - Sequence 370922 from Patent EP1572962.
JD193937 - Sequence 174961 from Patent EP1572962.
JD202674 - Sequence 183698 from Patent EP1572962.
JD051232 - Sequence 32256 from Patent EP1572962.
JD099949 - Sequence 80973 from Patent EP1572962.
JD439817 - Sequence 420841 from Patent EP1572962.
JD419394 - Sequence 400418 from Patent EP1572962.
JD465641 - Sequence 446665 from Patent EP1572962.
JD431712 - Sequence 412736 from Patent EP1572962.
JD088773 - Sequence 69797 from Patent EP1572962.
JD277456 - Sequence 258480 from Patent EP1572962.
JD189622 - Sequence 170646 from Patent EP1572962.
JD195776 - Sequence 176800 from Patent EP1572962.
JD539178 - Sequence 520202 from Patent EP1572962.
JD392284 - Sequence 373308 from Patent EP1572962.
JD330274 - Sequence 311298 from Patent EP1572962.
JD470040 - Sequence 451064 from Patent EP1572962.
JD039410 - Sequence 20434 from Patent EP1572962.
JD040023 - Sequence 21047 from Patent EP1572962.
JD370883 - Sequence 351907 from Patent EP1572962.
JD333907 - Sequence 314931 from Patent EP1572962.
JD469453 - Sequence 450477 from Patent EP1572962.
JD045962 - Sequence 26986 from Patent EP1572962.
JD103937 - Sequence 84961 from Patent EP1572962.
JD191497 - Sequence 172521 from Patent EP1572962.
JD062260 - Sequence 43284 from Patent EP1572962.
JD403617 - Sequence 384641 from Patent EP1572962.
JD237129 - Sequence 218153 from Patent EP1572962.
JD392987 - Sequence 374011 from Patent EP1572962.
JD152745 - Sequence 133769 from Patent EP1572962.
JD493401 - Sequence 474425 from Patent EP1572962.
JD052922 - Sequence 33946 from Patent EP1572962.
JD069509 - Sequence 50533 from Patent EP1572962.
JD425702 - Sequence 406726 from Patent EP1572962.
JD278151 - Sequence 259175 from Patent EP1572962.
JD476598 - Sequence 457622 from Patent EP1572962.
JD263981 - Sequence 245005 from Patent EP1572962.
JD489716 - Sequence 470740 from Patent EP1572962.
JD044472 - Sequence 25496 from Patent EP1572962.
JD338246 - Sequence 319270 from Patent EP1572962.
JD391042 - Sequence 372066 from Patent EP1572962.
JD217188 - Sequence 198212 from Patent EP1572962.
JD477512 - Sequence 458536 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04144 - Endocytosis
hsa04370 - VEGF signaling pathway
hsa04510 - Focal adhesion
hsa04520 - Adherens junction
hsa04530 - Tight junction
hsa04540 - Gap junction
hsa04912 - GnRH signaling pathway
hsa05100 - Bacterial invasion of epithelial cells
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection

Reactome (by CSHL, EBI, and GO)

Protein P12931 (Reactome details) participates in the following event(s):

R-HSA-170991 Activation of SRC by RAL-GTP
R-HSA-418170 Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex
R-HSA-418176 Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex
R-HSA-4420140 SRC1-1 binds SH2D2A and is recruited to VEGFR2
R-HSA-5218645 SRC-1 binds p-Y397-PTK2
R-HSA-5666104 RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes
R-HSA-443439 c-Src binds Raf1
R-HSA-177937 Phosphorylation of EGFR by SRC kinase
R-HSA-1295609 SRC phosphorylates SPRY2 on Y55 and Y227
R-HSA-5607750 SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan
R-HSA-4420206 Phosphorylation of SRC-1
R-HSA-5218643 HSP90AA1 binds p-6Y-VEGFR2
R-HSA-5218640 SRC-1 phosphorylates p-Y397-PTK2
R-HSA-5218838 PXN binds p-6Y,S732-PTK2
R-HSA-5218855 BCAR1 binds p-7Y-PTK2
R-HSA-5218851 p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407
R-HSA-5218826 Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
R-HSA-205205 Interaction of Src family kinases with p-KIT
R-HSA-388833 Phosphorylation of CTLA-4
R-HSA-418868 Recruitment of Src and Fyn to DCC:FADK1
R-HSA-3928615 EFNBs bind SFKs
R-HSA-3928584 p-EPHs bind SRC,FYN,YES,LYN
R-HSA-8855747 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP
R-HSA-377640 Autophosphorylation of SRC
R-HSA-391866 Phosphorylation of FAK by Src kinase
R-HSA-418859 Phosphorylation of Unc5C
R-HSA-445084 Phosphorylation of L1 by SRC
R-HSA-4420121 SFKs phosphorylate PLCG1
R-HSA-4420128 SRC-1 phosphorylates SHB
R-HSA-8948143 p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18
R-HSA-5357432 AXL binds SRC-1
R-HSA-8857925 Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
R-HSA-5218820 Src kinases phosphorylate VAV
R-HSA-5218830 SRC-1 phosphorylates PTK2-beta
R-HSA-5218809 PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118
R-HSA-5218828 PTK2/SRC-1 phosphorylates BCAR1
R-HSA-205238 SHP2 interacts with p-KIT
R-HSA-205319 Interaction of APS and p-KIT
R-HSA-1433451 JAK2 binds to p-KIT
R-HSA-1472121 Phosphorylation of p-KIT on Y900 by Src kinases
R-HSA-388829 SHP2 phosphatase binds CTLA-4
R-HSA-210291 Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
R-HSA-388831 Phosphorylation of CD28
R-HSA-373716 DCC interacting NCK-1
R-HSA-374701 Phosphorylation of DCC by Fyn
R-HSA-3928639 p-EFNB binds GRB4
R-HSA-3928580 SFKs phosphorylate EFNBs
R-HSA-391156 Phosphorylation of ITIM motif in SIRP alpha
R-HSA-3928623 EPHBs bind NMDARs
R-HSA-3928607 p-EPHs bind VAV2,3
R-HSA-3928602 NGEF binds EPHA
R-HSA-4093327 EPHA binds TIAM1
R-HSA-5357429 AXL autophosphorylates on Y772 and Y814
R-HSA-5357479 p-AXL binds PI3K
R-HSA-5672969 Phosphorylation of RAF
R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS
R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated
R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
R-HSA-8942607 Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
R-HSA-5218822 CRK binds BCAR1 and or PXN
R-HSA-1433506 Phosphorylation of APS
R-HSA-1433488 Phosphorylation of SHP2 by SFKs
R-HSA-1433418 Phosphorylation of JAK2
R-HSA-1433456 Recruitment of STATs
R-HSA-1433428 GRB2 is indirectly recruited to p-KIT through SHP2
R-HSA-1470012 Disassociation and translocation of STATs to the nucleus
R-HSA-1470010 Dimerization of STATs
R-HSA-1433542 Phosphorylation and activation of VAV1
R-HSA-418858 RhoGTPase GEF's recruited to DCC
R-HSA-418863 Shp2 binds pUnc5C
R-HSA-3928614 EFNB:GRB4 binds GIT1
R-HSA-3928594 SFKs phosphorylate GIT1
R-HSA-3928645 EPHB:NMDAR binds TIAM1
R-HSA-3928583 FYN phosphorylates NMDAR2B
R-HSA-3928604 SFKs phosphorylate VAV2,3
R-HSA-3928648 SFKs phosphorylate NGEF
R-HSA-5218811 DOCK180:ELMO binds CRK
R-HSA-205244 Recruitment of CBL to KIT
R-HSA-205234 Indirect recruitment of GAB2 to p-KIT
R-HSA-418850 Activation of Cdc42
R-HSA-418856 Activation of Rac1
R-HSA-3928631 GIT1 binds bPIX
R-HSA-3928627 EPHB phosphorylates TIAM1
R-HSA-3928628 VAV exchanges GTP for GDP on RAC1, activating it
R-HSA-3928642 TIAM1 exchanges GTP for GDP on RAC1, activating it
R-HSA-3928651 NGEF exchanges GTP for GDP on RHOA
R-HSA-5218839 DOCK180:ELMO exchanges GTP for GDP, activating RAC1
R-HSA-1562641 Indirect recruitment of PI3K to KIT via p(Y)-GAB2
R-HSA-418874 Recruitment and activation of N-WASP by Cdc42
R-HSA-418865 Recruitment of ABLIM to the plasma membrane
R-HSA-3928633 bPIX exchanges GTP for GDP on RAC, activating it
R-HSA-4093336 p-TIAM1 exchanges GTP for GDP on RAC1, activating it
R-HSA-5218819 VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
R-HSA-3928641 PAK binds RAC and bPIX
R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K
R-HSA-3928625 PAKs autophosphorylate
R-HSA-3928640 PAKs phosphorylate MLC
R-HSA-171007 p38MAPK events
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-167044 Signalling to RAS
R-HSA-177929 Signaling by EGFR
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-418885 DCC mediated attractive signaling
R-HSA-3928664 Ephrin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-8853659 RET signaling
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-392518 Signal amplification
R-HSA-194138 Signaling by VEGF
R-HSA-195258 RHO GTPase Effectors
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-418886 Netrin mediated repulsion signals
R-HSA-437239 Recycling pathway of L1
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-187687 Signalling to ERKs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1433559 Regulation of KIT signaling
R-HSA-388841 Costimulation by the CD28 family
R-HSA-210990 PECAM1 interactions
R-HSA-389356 CD28 co-stimulation
R-HSA-373752 Netrin-1 signaling
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-2029481 FCGR activation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-422475 Axon guidance
R-HSA-109582 Hemostasis
R-HSA-194315 Signaling by Rho GTPases
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-373760 L1CAM interactions
R-HSA-5205647 Mitophagy
R-HSA-5673000 RAF activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-69231 Cyclin D associated events in G1
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-162582 Signal Transduction
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654743 Signaling by FGFR4
R-HSA-168249 Innate Immune System
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-1280218 Adaptive Immune System
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-1500931 Cell-Cell communication
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-1266738 Developmental Biology
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-69236 G1 Phase
R-HSA-166520 Signaling by NTRKs
R-HSA-190236 Signaling by FGFR
R-HSA-168256 Immune System
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-5683057 MAPK family signaling cascades
R-HSA-1643685 Disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle
R-HSA-191654 c-src associates with Cx43 in gap junctions
R-HSA-191636 Phosphorylation of Cx43 by c-src
R-HSA-191656 Closure of gap junction
R-HSA-191647 c-src mediated regulation of Cx43 function and closure of gap junctions
R-HSA-191650 Regulation of gap junction activity
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8874083 p-Y397-PTK2 binds SRC
R-HSA-8937792 RUNX3 binds SRC
R-HSA-8937807 SRC phosphorylates RUNX3
R-HSA-186819 SH2 domain of Src binds to the active receptor
R-HSA-8937682 RUNX1 binds SRC
R-HSA-8937728 SRC phosphorylates RUNX1
R-HSA-177923 Sustained activation of SRC kinase by SHP2
R-HSA-380780 Activation of Src
R-HSA-8874082 MET phosphorylates PTK2
R-HSA-8874080 SRC phosphorylates PTK2
R-HSA-8937820 SRC,YES1 bind YAP1
R-HSA-8937844 SRC,YES1 phosphorylate YAP1
R-HSA-354077 Integrin alphaIIb beta3 activation
R-HSA-377641 Clustering of Integrin alphaIIb beta3 complexes
R-HSA-377643 Dephosphorylation of inactive SRC by PTPB1
R-HSA-377644 Release of CSK from SRC
R-HSA-354066 Translocation of FADK1 to Focal complexes
R-HSA-429415 SYK binds to integrin alphaIIb beta3
R-HSA-377640 Autophosphorylation of SRC
R-HSA-1963586 SRC family kinases phosphorylate ERBB2
R-HSA-9037040 SRC,FYN phosphorylate NTRK2
R-HSA-354149 Interaction of integrin alphaIIb beta3 with Fibrinogen
R-HSA-432096 Activated integrin alphaIIb beta3 binds SHC1
R-HSA-354087 Recruitment of GRB2 to p-FADK1
R-HSA-372705 Recruitment of p130Cas to FADK1
R-HSA-354124 Phosphorylation of pFADK1 by SRC
R-HSA-354073 Autophosphorylation of FADK1 at Y397
R-HSA-429441 SYK activation by SRC
R-HSA-354165 Interaction of SOS with GRB2 bound to FADK1
R-HSA-372697 Crk binding to p130cas
R-HSA-372693 Phosphorylation of p130Cas by SRC-FADK1 complex
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex
R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs
R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
R-HSA-5672980 Dissociation of RAS:RAF complex
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6803227 Dissociation of high activity BRAF complexes
R-HSA-6803230 Dissociation of moderate activity BRAF complexes
R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex
R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes
R-HSA-5672978 RAF phosphorylates MAP2K dimer
R-HSA-5672973 MAP2Ks phosphorylate MAPKs
R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks
R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-186763 Downstream signal transduction
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-180292 GAB1 signalosome
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
R-HSA-8875878 MET promotes cell motility
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-186797 Signaling by PDGF
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-177929 Signaling by EGFR
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-1227986 Signaling by ERBB2
R-HSA-8941326 RUNX2 regulates bone development
R-HSA-9032500 Activated NTRK2 signals through FYN
R-HSA-6806834 Signaling by MET
R-HSA-212436 Generic Transcription Pathway
R-HSA-5663205 Infectious disease
R-HSA-376176 Signaling by ROBO receptors
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-1643685 Disease
R-HSA-422475 Axon guidance
R-HSA-162582 Signal Transduction
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-166520 Signaling by NTRKs
R-HSA-74160 Gene expression (Transcription)
R-HSA-1266738 Developmental Biology
R-HSA-109582 Hemostasis
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5663202 Diseases of signal transduction
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades

-  Other Names for This Gene
  Alternate Gene Symbols: E1P5V4, NM_198291, NP_938033, P12931, Q76P87, Q86VB9, Q9H5A8, SRC1, SRC_HUMAN
UCSC ID: uc002xgy.3
RefSeq Accession: NM_198291
Protein: P12931 (aka SRC_HUMAN)
CCDS: CCDS13294.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198291.1
exon count: 14CDS single in 3' UTR: no RNA size: 4044
ORF size: 1611CDS single in intron: no Alignment % ID: 99.98
txCdsPredict score: 3377.00frame shift in genome: no % Coverage: 98.86
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.