Description: Homo sapiens transcription factor 23 (TCF23), mRNA. RefSeq Summary (NM_175769): The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. [provided by RefSeq, May 2010]. Transcript (Including UTRs) Position: hg19 chr2:27,371,945-27,375,819 Size: 3,875 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr2:27,372,002-27,375,735 Size: 3,734 Coding Exon Count: 3
ID:TCF23_HUMAN DESCRIPTION: RecName: Full=Transcription factor 23; Short=TCF-23; AltName: Full=Class A basic helix-loop-helix protein 24; Short=bHLHa24; FUNCTION: Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity). SUBUNIT: Forms inactive heterodimeric complexes with TCF3 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in liver, kidney and spleen. DOMAIN: Both the bHLH region and the C-terminal portion are essential for inhibitory function (By similarity). SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7RTU1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0046983 protein dimerization activity
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007517 muscle organ development GO:0010628 positive regulation of gene expression GO:0030154 cell differentiation GO:0046697 decidualization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
