Human Gene TMEM203 (uc004clv.3)
  Description: Homo sapiens transmembrane protein 203 (TMEM203), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:140,098,535-140,100,090 Size: 1,556 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr9:140,099,456-140,099,866 Size: 411 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:140,098,535-140,100,090)mRNA (may differ from genome)Protein (136 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM203_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 203;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -139.40224-0.622 Picture PostScript Text
3' UTR -295.20921-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019396 - TM_Fragile-X-F-assoc

Pfam Domains:
PF10269 - Transmembrane Fragile-X-F protein

ModBase Predicted Comparative 3D Structure on Q969S6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006874 cellular calcium ion homeostasis
GO:0007283 spermatogenesis

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC009283 - Homo sapiens transmembrane protein 203, mRNA (cDNA clone MGC:14327 IMAGE:4298098), complete cds.
BC009461 - Homo sapiens transmembrane protein 203, mRNA (cDNA clone MGC:15961 IMAGE:3538818), complete cds.
BC067786 - Homo sapiens transmembrane protein 203, mRNA (cDNA clone MGC:87188 IMAGE:5275460), complete cds.
AX775751 - Sequence 21 from Patent WO03048202.
JD420926 - Sequence 401950 from Patent EP1572962.
AF529372 - Homo sapiens HBeAg-binding protein 1 (HBEBP1) mRNA, complete cds.
JD138679 - Sequence 119703 from Patent EP1572962.
JD279919 - Sequence 260943 from Patent EP1572962.
JD253841 - Sequence 234865 from Patent EP1572962.
JD133651 - Sequence 114675 from Patent EP1572962.
JD507676 - Sequence 488700 from Patent EP1572962.
JD465756 - Sequence 446780 from Patent EP1572962.
KJ895223 - Synthetic construct Homo sapiens clone ccsbBroadEn_04617 TMEM203 gene, encodes complete protein.
JD025978 - Sequence 7002 from Patent EP1572962.
JD034436 - Sequence 15460 from Patent EP1572962.
JD024593 - Sequence 5617 from Patent EP1572962.
JD022441 - Sequence 3465 from Patent EP1572962.
DQ592367 - Homo sapiens piRNA piR-59479, complete sequence.
JD458750 - Sequence 439774 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_053045, NP_444273, Q6NW08, Q969S6, TM203_HUMAN
UCSC ID: uc004clv.3
RefSeq Accession: NM_053045
Protein: Q969S6 (aka TM203_HUMAN)
CCDS: CCDS35185.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_053045.1
exon count: 1CDS single in 3' UTR: no RNA size: 1576
ORF size: 411CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1022.00frame shift in genome: no % Coverage: 98.73
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.