Human Gene TXNDC12 (uc001cti.4)
Description: Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum) (TXNDC12), transcript variant 1, mRNA.
RefSeq Summary (NM_015913): This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012].
Transcript (Including UTRs)
Position: hg19 chr1:52,485,804-52,521,843 Size: 36,040 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr1:52,486,605-52,520,768 Size: 34,164 Coding Exon Count: 7
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TXD12_HUMAN
DESCRIPTION: RecName: Full=Thioredoxin domain-containing protein 12; EC=1.8.4.2; AltName: Full=Endoplasmic reticulum resident protein 18; Short=ER protein 18; Short=ERp18; AltName: Full=Endoplasmic reticulum resident protein 19; Short=ER protein 19; Short=ERp19; AltName: Full=Thioredoxin-like protein p19; AltName: Full=hTLP19; Flags: Precursor;
FUNCTION: Possesses significant protein thiol-disulfide oxidase activity.CATALYTIC ACTIVITY: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn; pH dependence: Optimum pH is 6.5;SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.TISSUE SPECIFICITY: Widely expressed.SIMILARITY: Contains 1 thioredoxin domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR012336 - Thioredoxin-like_fold
IPR017937 - Thioredoxin_CS
Pfam Domains: PF00085 - Thioredoxin
PF13899 - Thioredoxin-like
SCOP Domains: 52833 - Thioredoxin-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on O95881
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding
GO:0015037 peptide disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0019153 protein-disulfide reductase (glutathione) activity
Biological Process: GO:0030154 cell differentiation
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Cellular Component: GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Descriptions from all associated GenBank mRNAs
LF206548 - JP 2014500723-A/14051: Polycomb-Associated Non-Coding RNAs.BC008953 - Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum), mRNA (cDNA clone MGC:3735 IMAGE:2959502), complete cds.BC001493 - Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum), mRNA (cDNA clone MGC:1825 IMAGE:3506109), complete cds.AF131758 - Homo sapiens clone 24952 mRNA sequence, complete cds.AF543416 - Homo sapiens thioredoxin-like protein p19 (TLP19) mRNA, complete cds.AK075409 - Homo sapiens cDNA PSEC0100 fis, clone NT2RP2002927, highly similar to Thioredoxin domain-containing protein 12 precursor (EC 1.8.4.2).AK056169 - Homo sapiens cDNA FLJ31607 fis, clone NT2RI2002819, weakly similar to PUTATIVE SECRETED PROTEIN XAG PRECURSOR.BC008913 - Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum), mRNA (cDNA clone MGC:15395 IMAGE:3659407), complete cds.JD540093 - Sequence 521117 from Patent EP1572962.LF356117 - JP 2014500723-A/163620: Polycomb-Associated Non-Coding RNAs.LF356116 - JP 2014500723-A/163619: Polycomb-Associated Non-Coding RNAs.AY358982 - Homo sapiens clone DNA67300 ETRP713 (UNQ713) mRNA, complete cds.JD503174 - Sequence 484198 from Patent EP1572962.JD524550 - Sequence 505574 from Patent EP1572962.JD316285 - Sequence 297309 from Patent EP1572962.JD130242 - Sequence 111266 from Patent EP1572962.JD073388 - Sequence 54412 from Patent EP1572962.JD469454 - Sequence 450478 from Patent EP1572962.LF356115 - JP 2014500723-A/163618: Polycomb-Associated Non-Coding RNAs.JD248368 - Sequence 229392 from Patent EP1572962.HQ448666 - Synthetic construct Homo sapiens clone IMAGE:100072107; CCSB003545_01 thioredoxin domain containing 12 (endoplasmic reticulum) (TXNDC12) gene, encodes complete protein.KJ893793 - Synthetic construct Homo sapiens clone ccsbBroadEn_03187 TXNDC12 gene, encodes complete protein.KJ898811 - Synthetic construct Homo sapiens clone ccsbBroadEn_08205 TXNDC12 gene, encodes complete protein.CU674738 - Synthetic construct Homo sapiens gateway clone IMAGE:100017963 5' read TXNDC12 mRNA.AK094262 - Homo sapiens cDNA FLJ36943 fis, clone BRACE2005562.LF356112 - JP 2014500723-A/163615: Polycomb-Associated Non-Coding RNAs.LF356107 - JP 2014500723-A/163610: Polycomb-Associated Non-Coding RNAs.LF356104 - JP 2014500723-A/163607: Polycomb-Associated Non-Coding RNAs.JD424199 - Sequence 405223 from Patent EP1572962.JD036968 - Sequence 17992 from Patent EP1572962.JD534656 - Sequence 515680 from Patent EP1572962.JD417270 - Sequence 398294 from Patent EP1572962.JD539630 - Sequence 520654 from Patent EP1572962.LF383514 - JP 2014500723-A/191017: Polycomb-Associated Non-Coding RNAs.MA619091 - JP 2018138019-A/191017: Polycomb-Associated Non-Coding RNAs.MA442125 - JP 2018138019-A/14051: Polycomb-Associated Non-Coding RNAs.MA591694 - JP 2018138019-A/163620: Polycomb-Associated Non-Coding RNAs.MA591693 - JP 2018138019-A/163619: Polycomb-Associated Non-Coding RNAs.MA591692 - JP 2018138019-A/163618: Polycomb-Associated Non-Coding RNAs.MA591689 - JP 2018138019-A/163615: Polycomb-Associated Non-Coding RNAs.MA591684 - JP 2018138019-A/163610: Polycomb-Associated Non-Coding RNAs.MA591681 - JP 2018138019-A/163607: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00480 - Glutathione metabolism
Other Names for This Gene
Alternate Gene Symbols: B3KQS0, NM_015913, NP_056997, O95881, Q5T1T4, Q96H50, TLP19, TXD12_HUMAN, uc001cti.3, UNQ713/PRO1376UCSC ID: uc001cti.4RefSeq Accession: NM_015913
Protein: O95881
(aka TXD12_HUMAN)
CCDS: CCDS561.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_015913.3
exon count:
7 CDS single in 3' UTR:
no
RNA size:
2412
ORF size:
519 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
1040.00 frame shift in genome:
no
% Coverage:
99.30
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.