Mouse Gene Cd55 (ENSMUST00000027650.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus CD55 molecule, decay accelerating factor for complement (Cd55), mRNA. (from RefSeq NM_010016) RefSeq Summary (NM_010016): This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENSMUST00000027650.12 Gencode Gene: ENSMUSG00000026399.12 Transcript (Including UTRs) Position: mm10 chr1:130,439,027-130,462,744 Size: 23,718 Total Exon Count: 10 Strand: - Coding Region Position: mm10 chr1:130,440,312-130,462,669 Size: 22,358 Coding Exon Count: 10
ID:DAF1_MOUSE DESCRIPTION: RecName: Full=Complement decay-accelerating factor, GPI-anchored; Short=DAF-GPI; AltName: CD_antigen=CD55; Flags: Precursor; FUNCTION: Protection of cells from complement-mediated damage (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). TISSUE SPECIFICITY: Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node. DOMAIN: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity). SIMILARITY: Belongs to the receptors of complement activation (RCA) family. SIMILARITY: Contains 4 Sushi (CCP/SCR) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q61475
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.