Mouse Gene Cd55 (ENSMUST00000027650.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus CD55 molecule, decay accelerating factor for complement (Cd55), mRNA. (from RefSeq NM_010016)
RefSeq Summary (NM_010016): This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENSMUST00000027650.12
Gencode Gene: ENSMUSG00000026399.12
Transcript (Including UTRs)
   Position: mm10 chr1:130,439,027-130,462,744 Size: 23,718 Total Exon Count: 10 Strand: -
Coding Region
   Position: mm10 chr1:130,440,312-130,462,669 Size: 22,358 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:130,439,027-130,462,744)mRNA (may differ from genome)Protein (390 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DAF1_MOUSE
DESCRIPTION: RecName: Full=Complement decay-accelerating factor, GPI-anchored; Short=DAF-GPI; AltName: CD_antigen=CD55; Flags: Precursor;
FUNCTION: Protection of cells from complement-mediated damage (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).
TISSUE SPECIFICITY: Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.
DOMAIN: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
SIMILARITY: Belongs to the receptors of complement activation (RCA) family.
SIMILARITY: Contains 4 Sushi (CCP/SCR) domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • D004958 Estradiol
  • D004997 Ethinyl Estradiol
  • D010634 Phenobarbital
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C017906 3-dinitrobenzene
          more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.3075-0.324 Picture PostScript Text
3' UTR -285.701285-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016060 - Complement_control_module
IPR000436 - Sushi_SCR_CCP

Pfam Domains:
PF00084 - Sushi repeat (SCR repeat)

SCOP Domains:
57535 - Complement control module/SCR domain
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q61475
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001618 virus receptor activity
GO:0004857 enzyme inhibitor activity
GO:0008289 lipid binding

Biological Process:
GO:0002376 immune system process
GO:0006958 complement activation, classical pathway
GO:0030450 regulation of complement activation, classical pathway
GO:0043086 negative regulation of catalytic activity
GO:0045087 innate immune response
GO:0045916 negative regulation of complement activation
GO:0046718 viral entry into host cell

Cellular Component:
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  AK160994 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:4022433J04 product:decay accelerating factor 1, full insert sequence.
D63679 - Mus musculus DAF mRNA for decay-accelerating factor precursor, partial cds.
BC011314 - Mus musculus CD55 antigen, mRNA (cDNA clone MGC:18419 IMAGE:3663561), complete cds.
L41366 - Mus musculus decay-accelerating factor GPI-anchored (Daf-GPI) mRNA, complete cds.
CT010328 - Mus musculus full open reading frame cDNA clone RZPDo836E0552D for gene Daf1, Decay accelerating factor 1; complete cds, incl. stopcodon.
AK030285 - Mus musculus 11 days pregnant adult female ovary and uterus cDNA, RIKEN full-length enriched library, clone:5031405O06 product:decay accelerating factor 1, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04610 - Complement and coagulation cascades
mmu04640 - Hematopoietic cell lineage
mmu05416 - Viral myocarditis

Reactome (by CSHL, EBI, and GO)

Protein Q61475 (Reactome details) participates in the following event(s):

R-MMU-879674 CD97 binds CD55
R-MMU-981535 CD55 (DAF) binds C3bBb, C4bC2a
R-MMU-977619 CD55 (DAF) promotes C3bBb/C4bC2a dissociation
R-MMU-6798743 Exocytosis of secretory granule membrane proteins
R-MMU-6800426 Exocytosis of ficolin-rich granule membrane proteins
R-MMU-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex
R-MMU-6807877 ARFGAPs stimulate ARF GTPase activity
R-MMU-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin
R-MMU-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex
R-MMU-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle
R-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-977606 Regulation of Complement cascade
R-MMU-500792 GPCR ligand binding
R-MMU-6798695 Neutrophil degranulation
R-MMU-166658 Complement cascade
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-372790 Signaling by GPCR
R-MMU-168249 Innate Immune System
R-MMU-199977 ER to Golgi Anterograde Transport
R-MMU-162582 Signal Transduction
R-MMU-168256 Immune System
R-MMU-199991 Membrane Trafficking
R-MMU-948021 Transport to the Golgi and subsequent modification
R-MMU-5653656 Vesicle-mediated transport
R-MMU-446203 Asparagine N-linked glycosylation
R-MMU-597592 Post-translational protein modification
R-MMU-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: Cd55a, Daf, Daf1, DAF1_MOUSE, NM_010016, P97732, Q3TU32, Q4FJS4, Q61397, Q61475, Q76N72, Q921P0, Q9R1C1, uc007cly.1, uc007cly.2, uc007cly.3
UCSC ID: uc007cly.3
RefSeq Accession: NM_010016
Protein: Q61475 (aka DAF1_MOUSE)
CCDS: CCDS15256.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.