Human Gene ANGPTL7 (ENST00000376819.4) from GENCODE V41
  Description: Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA. (from RefSeq NM_021146)
Gencode Transcript: ENST00000376819.4
Gencode Gene: ENSG00000171819.5
Transcript (Including UTRs)
   Position: hg38 chr1:11,189,355-11,195,981 Size: 6,627 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr1:11,189,580-11,195,023 Size: 5,444 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2022-05-14 09:57:26

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:11,189,355-11,195,981)mRNA (may differ from genome)Protein (346 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGencode

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Angiopoietin-related protein 7; AltName: Full=Angiopoietin-like factor; AltName: Full=Angiopoietin-like protein 7; AltName: Full=Cornea-derived transcript 6 protein; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Probable).
TISSUE SPECIFICITY: Highly and specifically expressed in the cornea where is confined to the stromal layer.
SIMILARITY: Contains 1 fibrinogen C-terminal domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 374.59 RPKM in Nerve - Tibial
Total median expression: 440.59 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.20225-0.272 Picture PostScript Text
3' UTR -254.70958-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002181 - Fibrinogen_a/b/g_C
IPR014716 - Fibrinogen_a/b/g_C_1
IPR014715 - Fibrinogen_a/b/g_C_2

Pfam Domains:
PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain

ModBase Predicted Comparative 3D Structure on O43827
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006979 response to oxidative stress

Cellular Component:
GO:0005576 extracellular region

-  Descriptions from all associated GenBank mRNAs
  LF213890 - JP 2014500723-A/21393: Polycomb-Associated Non-Coding RNAs.
MA449467 - JP 2018138019-A/21393: Polycomb-Associated Non-Coding RNAs.
AB593027 - Homo sapiens ANGPTL7 mRNA for angiopoietin-related protein 7, complete cds, clone: HP04607-ARiS049I20.
AK313716 - Homo sapiens cDNA, FLJ94309, Homo sapiens angiopoietin-like factor (CDT6), mRNA.
BC001881 - Homo sapiens angiopoietin-like 7, mRNA (cDNA clone MGC:1422 IMAGE:3544149), complete cds.
LF206725 - JP 2014500723-A/14228: Polycomb-Associated Non-Coding RNAs.
MA442302 - JP 2018138019-A/14228: Polycomb-Associated Non-Coding RNAs.
AB593026 - Homo sapiens ANGPTL7 mRNA for angiopoietin-related protein 7, complete cds, clone: HP04607-ARi15F09.
JD311139 - Sequence 292163 from Patent EP1572962.
AY358301 - Homo sapiens clone DNA47470 NL4 (UNQ313) mRNA, complete cds.
LF357380 - JP 2014500723-A/164883: Polycomb-Associated Non-Coding RNAs.
MA592957 - JP 2018138019-A/164883: Polycomb-Associated Non-Coding RNAs.
JD360799 - Sequence 341823 from Patent EP1572962.
Y16132 - Homo sapiens mRNA for angiopoietin-like factor.
CU674908 - Synthetic construct Homo sapiens gateway clone IMAGE:100019043 5' read ANGPTL7 mRNA.
DQ895766 - Synthetic construct Homo sapiens clone IMAGE:100010226; FLH187435.01L; RZPDo839H0462D angiopoietin-like 7 (ANGPTL7) gene, encodes complete protein.
BT009802 - Homo sapiens angiopoietin-like factor mRNA, complete cds.
DQ892555 - Synthetic construct clone IMAGE:100005185; FLH187439.01X; RZPDo839H0472D angiopoietin-like 7 (ANGPTL7) gene, encodes complete protein.
KJ892965 - Synthetic construct Homo sapiens clone ccsbBroadEn_02359 ANGPTL7 gene, encodes complete protein.
LF357379 - JP 2014500723-A/164882: Polycomb-Associated Non-Coding RNAs.
MA592956 - JP 2018138019-A/164882: Polycomb-Associated Non-Coding RNAs.
LF357378 - JP 2014500723-A/164881: Polycomb-Associated Non-Coding RNAs.
MA592955 - JP 2018138019-A/164881: Polycomb-Associated Non-Coding RNAs.
LF357377 - JP 2014500723-A/164880: Polycomb-Associated Non-Coding RNAs.
MA592954 - JP 2018138019-A/164880: Polycomb-Associated Non-Coding RNAs.
LF357376 - JP 2014500723-A/164879: Polycomb-Associated Non-Coding RNAs.
MA592953 - JP 2018138019-A/164879: Polycomb-Associated Non-Coding RNAs.
LF357375 - JP 2014500723-A/164878: Polycomb-Associated Non-Coding RNAs.
MA592952 - JP 2018138019-A/164878: Polycomb-Associated Non-Coding RNAs.
JD511838 - Sequence 492862 from Patent EP1572962.
JD441069 - Sequence 422093 from Patent EP1572962.
JD051432 - Sequence 32456 from Patent EP1572962.
JD060449 - Sequence 41473 from Patent EP1572962.
JD332713 - Sequence 313737 from Patent EP1572962.
JD499207 - Sequence 480231 from Patent EP1572962.
LF357374 - JP 2014500723-A/164877: Polycomb-Associated Non-Coding RNAs.
MA592951 - JP 2018138019-A/164877: Polycomb-Associated Non-Coding RNAs.
JD487737 - Sequence 468761 from Patent EP1572962.
JD227190 - Sequence 208214 from Patent EP1572962.
JD255070 - Sequence 236094 from Patent EP1572962.
JD299628 - Sequence 280652 from Patent EP1572962.
JD359972 - Sequence 340996 from Patent EP1572962.
JD564731 - Sequence 545755 from Patent EP1572962.
JD499225 - Sequence 480249 from Patent EP1572962.
JD440192 - Sequence 421216 from Patent EP1572962.
JD480013 - Sequence 461037 from Patent EP1572962.
JD468267 - Sequence 449291 from Patent EP1572962.
JD308514 - Sequence 289538 from Patent EP1572962.
JD073397 - Sequence 54421 from Patent EP1572962.
JD157378 - Sequence 138402 from Patent EP1572962.
JD392930 - Sequence 373954 from Patent EP1572962.
JD271803 - Sequence 252827 from Patent EP1572962.
JD165653 - Sequence 146677 from Patent EP1572962.
LF357373 - JP 2014500723-A/164876: Polycomb-Associated Non-Coding RNAs.
MA592950 - JP 2018138019-A/164876: Polycomb-Associated Non-Coding RNAs.
JD301920 - Sequence 282944 from Patent EP1572962.
JD073524 - Sequence 54548 from Patent EP1572962.
JD155063 - Sequence 136087 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANGL7_HUMAN, B2R9B2, CDT6, ENST00000376819.1, ENST00000376819.2, ENST00000376819.3, NM_021146, O43827, Q4ZGK4, uc001ase.1, uc001ase.2, uc001ase.3, uc001ase.4, uc001ase.5, uc001ase.6, UNQ313/PRO356
UCSC ID: ENST00000376819.4
RefSeq Accession: NM_021146
Protein: O43827 (aka ANGL7_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.