Human Gene SIRT1 (ENST00000432464.5) from GENCODE V44
Description: Homo sapiens sirtuin 1 (SIRT1), transcript variant 2, mRNA. (from RefSeq NM_001142498) RefSeq Summary (NM_001142498): This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]. Gencode Transcript: ENST00000432464.5 Gencode Gene: ENSG00000096717.12 Transcript (Including UTRs) Position: hg38 chr10:67,885,181-67,918,389 Size: 33,209 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr10:67,891,498-67,916,593 Size: 25,096 Coding Exon Count: 6
ID:E9PC49_HUMAN DESCRIPTION: SubName: Full=NAD-dependent protein deacetylase sirtuin-1; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E9PC49
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.