Human Gene NACA (ENST00000550920.6) from GENCODE V41
Description: Contains 1 NAC-A/B (NAC-alpha/beta) domain. (from UniProt H0YHX9) RefSeq Summary (NM_001113203): This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Gencode Transcript: ENST00000550920.6 Gencode Gene: ENSG00000196531.14 Transcript (Including UTRs) Position: hg38 chr12:56,712,428-56,725,286 Size: 12,859 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr12:56,712,538-56,724,521 Size: 11,984 Coding Exon Count: 8
ID:H0YHX9_HUMAN DESCRIPTION: SubName: Full=Nascent polypeptide-associated complex subunit alpha; Flags: Fragment; SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain. SIMILARITY: Contains 1 UBA domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on H0YHX9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.