Human Gene CLTRN (ENST00000650271.1) from GENCODE V41
  Description: collectrin, amino acid transport regulator (from HGNC CLTRN)
RefSeq Summary (NM_020665): This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013].
Gencode Transcript: ENST00000650271.1
Gencode Gene: ENSG00000147003.7
Transcript (Including UTRs)
   Position: hg38 chrX:15,627,439-15,675,012 Size: 47,574 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chrX:15,627,971-15,659,062 Size: 31,092 Coding Exon Count: 4 

Page IndexSequence and LinksRNA-Seq ExpressionMicroarray ExpressionRNA StructureOther Species
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2022-05-14 09:57:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:15,627,439-15,675,012)mRNA (may differ from genome)Protein (170 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGencodeGeneCardsMGIPubMed
UniProtKB

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.12 RPKM in Kidney - Cortex
Total median expression: 68.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -123.30529-0.233 Picture PostScript Text
3' UTR -105.11532-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  KM576721 - Homo sapiens clone TMEM27-ACE2_T4-A2middle mRNA sequence.
KM576722 - Homo sapiens clone TMEM27-ACE2_T4-A2 mRNA sequence.
KM576723 - Homo sapiens clone TMEM27-ACE2_T5-A2middle mRNA sequence.
KM576724 - Homo sapiens clone TMEM27-ACE2_T5-A2 mRNA sequence.
BC050606 - Homo sapiens transmembrane protein 27, mRNA (cDNA clone MGC:60059 IMAGE:5183554), complete cds.
AF229179 - Homo sapiens collectrin mRNA, complete cds.
BC015099 - Homo sapiens transmembrane protein 27, mRNA (cDNA clone MGC:22827 IMAGE:3829035), complete cds.
AY359060 - Homo sapiens clone DNA61873 NX-17 (UNQ678) mRNA, complete cds.
BC014317 - Homo sapiens transmembrane protein 27, mRNA (cDNA clone MGC:22707 IMAGE:4048217), complete cds.
JD245400 - Sequence 226424 from Patent EP1572962.
JD359085 - Sequence 340109 from Patent EP1572962.
JD273595 - Sequence 254619 from Patent EP1572962.
JD180122 - Sequence 161146 from Patent EP1572962.
AK313835 - Homo sapiens cDNA, FLJ94460, Homo sapiens kidney-specific membrane protein (NX17), mRNA.
KJ904836 - Synthetic construct Homo sapiens clone ccsbBroadEn_14230 TMEM27 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A3B3ITM8, BC050606, uc286crg.1
UCSC ID: ENST00000650271.1
RefSeq Accession: NM_020665

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.