Human Gene PRIM1 (ENST00000672280.1) from GENCODE V41
  Description: DNA primase subunit 1 (from HGNC PRIM1)
RefSeq Summary (NM_000946): The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000672280.1
Gencode Gene: ENSG00000198056.15
Transcript (Including UTRs)
   Position: hg38 chr12:56,731,296-56,752,374 Size: 21,079 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr12:56,731,715-56,752,298 Size: 20,584 Coding Exon Count: 14 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2022-05-14 09:57:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:56,731,296-56,752,374)mRNA (may differ from genome)Protein (459 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMGIPubMedUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D010634 Phenobarbital
  • C006780 bisphenol A
  • C006253 pirinixic acid
  • C049325 1,2-dithiol-3-thione
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C023514 2,6-dinitrotoluene
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.62 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 130.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.0076-0.382 Picture PostScript Text
3' UTR -127.30419-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  JD112109 - Sequence 93133 from Patent EP1572962.
JD112108 - Sequence 93132 from Patent EP1572962.
JD512583 - Sequence 493607 from Patent EP1572962.
JD412655 - Sequence 393679 from Patent EP1572962.
JD197732 - Sequence 178756 from Patent EP1572962.
JD212328 - Sequence 193352 from Patent EP1572962.
JD212327 - Sequence 193351 from Patent EP1572962.
JD512581 - Sequence 493605 from Patent EP1572962.
JD412654 - Sequence 393678 from Patent EP1572962.
JD140086 - Sequence 121110 from Patent EP1572962.
JD542521 - Sequence 523545 from Patent EP1572962.
JD409681 - Sequence 390705 from Patent EP1572962.
JD497644 - Sequence 478668 from Patent EP1572962.
AK223391 - Homo sapiens mRNA for DNA primase small subunit, 49kDa variant, clone: FCC107C02.
X74330 - H.sapiens mRNA for DNA primase (subunit p48).
BC005266 - Homo sapiens primase, DNA, polypeptide 1 (49kDa), mRNA (cDNA clone MGC:12308 IMAGE:3686937), complete cds.
AK314866 - Homo sapiens cDNA, FLJ95767, highly similar to Homo sapiens primase, polypeptide 1, 49kDa (PRIM1), mRNA.
KJ891881 - Synthetic construct Homo sapiens clone ccsbBroadEn_01275 PRIM1 gene, encodes complete protein.
EU176421 - Synthetic construct Homo sapiens clone IMAGE:100006499; FLH193115.01X; RZPDo839D06252D primase, DNA, polypeptide 1 (49kDa) (PRIM1) gene, encodes complete protein.
EU176762 - Synthetic construct Homo sapiens clone IMAGE:100011533; FLH193111.01L; RZPDo839A02256D primase, DNA, polypeptide 1 (49kDa) (PRIM1) gene, encodes complete protein.
AB528338 - Synthetic construct DNA, clone: pF1KB0958, Homo sapiens PRIM1 gene for primase, DNA, polypeptide 1, without stop codon, in Flexi system.
JD265858 - Sequence 246882 from Patent EP1572962.
JD063862 - Sequence 44886 from Patent EP1572962.
JD265857 - Sequence 246881 from Patent EP1572962.
CU675073 - Synthetic construct Homo sapiens gateway clone IMAGE:100017229 5' read PRIM1 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism
hsa00240 - Pyrimidine metabolism
hsa01100 - Metabolic pathways
hsa03030 - DNA replication

-  Other Names for This Gene
  Alternate Gene Symbols: A0A5F9ZHB6, BC005266, uc288lla.1
UCSC ID: ENST00000672280.1
RefSeq Accession: NM_000946

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.