Human Gene RFESD (ENST00000380005.9) from GENCODE V44
  Description: Homo sapiens Rieske Fe-S domain containing (RFESD), transcript variant 3, mRNA. (from RefSeq NM_001131066)
Gencode Transcript: ENST00000380005.9
Gencode Gene: ENSG00000175449.15
Transcript (Including UTRs)
   Position: hg38 chr5:95,646,777-95,658,082 Size: 11,306 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr5:95,652,272-95,656,309 Size: 4,038 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:95,646,777-95,658,082)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RFESD_HUMAN
DESCRIPTION: RecName: Full=Rieske domain-containing protein;
COFACTOR: Binds 1 2Fe-2S cluster per subunit (By similarity).
SIMILARITY: Contains 1 Rieske domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.61 RPKM in Testis
Total median expression: 12.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.60176-0.225 Picture PostScript Text
3' UTR -424.701773-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017941 - Rieske_2Fe-2S

ModBase Predicted Comparative 3D Structure on Q8TAC1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process:
GO:0055114 oxidation-reduction process


-  Descriptions from all associated GenBank mRNAs
  BC048979 - Homo sapiens Rieske (Fe-S) domain containing, mRNA (cDNA clone MGC:57355 IMAGE:4838006), complete cds.
BC035110 - Homo sapiens Rieske (Fe-S) domain containing, mRNA (cDNA clone MGC:43188 IMAGE:5262922), complete cds.
BC024023 - Homo sapiens Rieske (Fe-S) domain containing, mRNA (cDNA clone MGC:27344 IMAGE:4670524), complete cds.
JD371384 - Sequence 352408 from Patent EP1572962.
KJ896027 - Synthetic construct Homo sapiens clone ccsbBroadEn_05421 RFESD gene, encodes complete protein.
JD328681 - Sequence 309705 from Patent EP1572962.
JD509409 - Sequence 490433 from Patent EP1572962.
JD041915 - Sequence 22939 from Patent EP1572962.
JD061440 - Sequence 42464 from Patent EP1572962.
JD284393 - Sequence 265417 from Patent EP1572962.
JD186568 - Sequence 167592 from Patent EP1572962.
JD170786 - Sequence 151810 from Patent EP1572962.
JD071628 - Sequence 52652 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000380005.1, ENST00000380005.2, ENST00000380005.3, ENST00000380005.4, ENST00000380005.5, ENST00000380005.6, ENST00000380005.7, ENST00000380005.8, J3KPH1, NM_001131066, Q8TAC1, RFESD_HUMAN, uc003klg.1, uc003klg.2, uc003klg.3, uc003klg.4, uc003klg.5
UCSC ID: ENST00000380005.9
RefSeq Accession: NM_001131066
Protein: Q8TAC1 (aka RFESD_HUMAN)
CCDS: CCDS47248.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.