Human Gene ZNF578 (ENST00000421239.7) from GENCODE V44
  Description: Homo sapiens zinc finger protein 578 (ZNF578), transcript variant 2, mRNA. (from RefSeq NM_001366182)
Gencode Transcript: ENST00000421239.7
Gencode Gene: ENSG00000258405.11
Transcript (Including UTRs)
   Position: hg38 chr19:52,453,553-52,516,882 Size: 63,330 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr19:52,501,846-52,512,154 Size: 10,309 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:52,453,553-52,516,882)mRNA (may differ from genome)Protein (590 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIneXtProtPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN578_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 578;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 12 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.02 RPKM in Testis
Total median expression: 9.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.00267-0.303 Picture PostScript Text
3' UTR -1712.904728-0.362 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q96N58
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  JD307268 - Sequence 288292 from Patent EP1572962.
AB091373 - Homo sapiens mRNA for hypothetical protein, complete cds, PCR product:LOC125890 isoform 1.
AB091374 - Homo sapiens mRNA for hypothetical protein, complete cds, PCR product:LOC125890 isoform 2.
AK299106 - Homo sapiens cDNA FLJ54871 complete cds, moderately similar to Zinc finger protein 611.
LP896116 - Sequence 980 from Patent EP3253886.
AL833487 - Homo sapiens mRNA; cDNA DKFZp686H1629 (from clone DKFZp686H1629).
AB091376 - Homo sapiens mRNA for hypothetical protein, complete cds, PCR product:LOC125890 isoform 4.
AB091375 - Homo sapiens mRNA for hypothetical protein, complete cds, PCR product:LOC125890 isoform 3.
DQ590730 - Homo sapiens piRNA piR-57842, complete sequence.
AK055946 - Homo sapiens cDNA FLJ31384 fis, clone NHNPC2000212, moderately similar to ZINC FINGER PROTEIN 83.
BC103904 - Homo sapiens zinc finger protein 578, mRNA (cDNA clone IMAGE:40005184), partial cds.
BC115704 - Homo sapiens zinc finger protein 578, mRNA (cDNA clone IMAGE:40005190), partial cds.
JD154636 - Sequence 135660 from Patent EP1572962.
KJ905617 - Synthetic construct Homo sapiens clone ccsbBroadEn_15256 ZNF578 gene, encodes complete protein.
JD086179 - Sequence 67203 from Patent EP1572962.
AK095562 - Homo sapiens cDNA FLJ38243 fis, clone FCBBF2006882, moderately similar to ZINC FINGER PROTEIN 83.
JD357710 - Sequence 338734 from Patent EP1572962.
JD357709 - Sequence 338733 from Patent EP1572962.
JD516147 - Sequence 497171 from Patent EP1572962.
JD247946 - Sequence 228970 from Patent EP1572962.
JD037125 - Sequence 18149 from Patent EP1572962.
JD082041 - Sequence 63065 from Patent EP1572962.
JD376511 - Sequence 357535 from Patent EP1572962.
JD249490 - Sequence 230514 from Patent EP1572962.
JD090066 - Sequence 71090 from Patent EP1572962.
JD090065 - Sequence 71089 from Patent EP1572962.
JD431470 - Sequence 412494 from Patent EP1572962.
JD247925 - Sequence 228949 from Patent EP1572962.
JD266669 - Sequence 247693 from Patent EP1572962.
JD266668 - Sequence 247692 from Patent EP1572962.
JD081994 - Sequence 63018 from Patent EP1572962.
JD490384 - Sequence 471408 from Patent EP1572962.
JD501195 - Sequence 482219 from Patent EP1572962.
JD348045 - Sequence 329069 from Patent EP1572962.
JD181804 - Sequence 162828 from Patent EP1572962.
JD384608 - Sequence 365632 from Patent EP1572962.
JD229706 - Sequence 210730 from Patent EP1572962.
JD536113 - Sequence 517137 from Patent EP1572962.
JD182684 - Sequence 163708 from Patent EP1572962.
JD084227 - Sequence 65251 from Patent EP1572962.
JD324246 - Sequence 305270 from Patent EP1572962.
JD413363 - Sequence 394387 from Patent EP1572962.
JD246884 - Sequence 227908 from Patent EP1572962.
JD194635 - Sequence 175659 from Patent EP1572962.
JD179309 - Sequence 160333 from Patent EP1572962.
JD179308 - Sequence 160332 from Patent EP1572962.
JD380547 - Sequence 361571 from Patent EP1572962.
JD043597 - Sequence 24621 from Patent EP1572962.
JD546449 - Sequence 527473 from Patent EP1572962.
JD220912 - Sequence 201936 from Patent EP1572962.
JD489110 - Sequence 470134 from Patent EP1572962.
JD310510 - Sequence 291534 from Patent EP1572962.
JD435376 - Sequence 416400 from Patent EP1572962.
JD518888 - Sequence 499912 from Patent EP1572962.
JD542667 - Sequence 523691 from Patent EP1572962.
JD212617 - Sequence 193641 from Patent EP1572962.
JD198005 - Sequence 179029 from Patent EP1572962.
JD413295 - Sequence 394319 from Patent EP1572962.
JD413296 - Sequence 394320 from Patent EP1572962.
JD246752 - Sequence 227776 from Patent EP1572962.
JD246753 - Sequence 227777 from Patent EP1572962.
JD208939 - Sequence 189963 from Patent EP1572962.
JD452911 - Sequence 433935 from Patent EP1572962.
JD558418 - Sequence 539442 from Patent EP1572962.
JD396556 - Sequence 377580 from Patent EP1572962.
JD282217 - Sequence 263241 from Patent EP1572962.
JD194944 - Sequence 175968 from Patent EP1572962.
JD545989 - Sequence 527013 from Patent EP1572962.
JD488046 - Sequence 469070 from Patent EP1572962.
JD077544 - Sequence 58568 from Patent EP1572962.
JD218214 - Sequence 199238 from Patent EP1572962.
JD421728 - Sequence 402752 from Patent EP1572962.
JD465759 - Sequence 446783 from Patent EP1572962.
JD437510 - Sequence 418534 from Patent EP1572962.
JD089614 - Sequence 70638 from Patent EP1572962.
JD279322 - Sequence 260346 from Patent EP1572962.
JD232830 - Sequence 213854 from Patent EP1572962.
JD548736 - Sequence 529760 from Patent EP1572962.
JD169347 - Sequence 150371 from Patent EP1572962.
JD169348 - Sequence 150372 from Patent EP1572962.
JD041367 - Sequence 22391 from Patent EP1572962.
JD388295 - Sequence 369319 from Patent EP1572962.
JD388296 - Sequence 369320 from Patent EP1572962.
JD118391 - Sequence 99415 from Patent EP1572962.
JD273654 - Sequence 254678 from Patent EP1572962.
JD217344 - Sequence 198368 from Patent EP1572962.
JD321478 - Sequence 302502 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000421239.1, ENST00000421239.2, ENST00000421239.3, ENST00000421239.4, ENST00000421239.5, ENST00000421239.6, NM_001366182, Q96N58, uc002pzp.1, uc002pzp.2, uc002pzp.3, uc002pzp.4, uc002pzp.5, uc002pzp.6, ZN578_HUMAN
UCSC ID: ENST00000421239.7
RefSeq Accession: NM_001099694
Protein: Q96N58 (aka ZN578_HUMAN or Z578_HUMAN)
CCDS: CCDS54310.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.