ID:Q9D6D0_MOUSE DESCRIPTION: SubName: Full=Protein Slc25a27; SubName: Full=Solute carrier family 25, member 27; SubName: Full=Solute carrier family 25, member 27, isoform CRA_a; SubName: Full=Uncoupling protein 4; SIMILARITY: Belongs to the mitochondrial carrier family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00153 - Mitochondrial carrier protein
ModBase Predicted Comparative 3D Structure on Q9D6D0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006839 mitochondrial transport GO:0008284 positive regulation of cell proliferation GO:0009409 response to cold GO:0010917 negative regulation of mitochondrial membrane potential GO:0035356 cellular triglyceride homeostasis GO:0043066 negative regulation of apoptotic process GO:0046324 regulation of glucose import GO:0048839 inner ear development GO:0051562 negative regulation of mitochondrial calcium ion concentration GO:0051881 regulation of mitochondrial membrane potential GO:0055085 transmembrane transport GO:0070997 neuron death
AK083270 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630032J21 product:inferred: RIKEN cDNA 3632410G24 gene, full insert sequence. AK084741 - Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330037G19 product:inferred: RIKEN cDNA 3632410G24 gene, full insert sequence. BC031371 - Mus musculus solute carrier family 25, member 27, mRNA (cDNA clone IMAGE:5006993), with apparent retained intron. AB106930 - Mus musculus UCP4 mRNA for uncoupling protein 4, complete cds. AK014394 - Mus musculus adult male brain cDNA, RIKEN full-length enriched library, clone:3632410G24 product:UNCOUPLING PROTEIN UCP-4, ISOFORM A homolog [Rattus norvegicus], full insert sequence. BC138993 - Mus musculus solute carrier family 25, member 27, mRNA (cDNA clone MGC:170620 IMAGE:8862015), complete cds. BC138994 - Mus musculus solute carrier family 25, member 27, mRNA (cDNA clone MGC:170621 IMAGE:8862016), complete cds. AK043831 - Mus musculus 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830038H13 product:UNCOUPLING PROTEIN UCP-4, ISOFORM A homolog [Rattus norvegicus], full insert sequence. AK219158 - Mus musculus cDNA, clone:Y2G0147I23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000024705, based on BLAT search. AK021314 - Mus musculus 13 days embryo stomach cDNA, RIKEN full-length enriched library, clone:D530043E16 product:similar to UNCOUPLING PROTEIN UCP-4, ISOFORM A [Rattus norvegicus], full insert sequence. AK054292 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330010P20 product:weakly similar to MITOCHONDRIAL UNCOUPLING PROTEIN 4 (UCP 4) [Homo sapiens], full insert sequence. BC099432 - Mus musculus cDNA clone IMAGE:30840315. BC060279 - Mus musculus cDNA clone IMAGE:30146772, partial cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9D6D0 (Reactome details) participates in the following event(s):
R-MMU-166220 FA anion diffuses laterally to UCP R-MMU-166387 The FA anion diffuses away laterally from UCP R-MMU-166214 FA anion flip-flops to the opposite surface R-MMU-170026 Protons are translocated from the intermembrane space to the matrix R-MMU-167826 The fatty acid cycling model R-MMU-166187 Mitochondrial Uncoupling Proteins R-MMU-167827 The proton buffering model R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport R-MMU-1430728 Metabolism