Mouse Gene Slc25a24 (ENSMUST00000029477.11) from GENCODE VM33
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 (Slc25a24), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_172685)
Gencode Transcript: ENSMUST00000029477.11
Gencode Gene: ENSMUSG00000040322.11
Transcript (Including UTRs)
   Position: mm39 chr3:109,030,465-109,075,773 Size: 45,309 Total Exon Count: 10 Strand: +
Coding Region
   Position: mm39 chr3:109,030,521-109,073,826 Size: 43,306 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-15 19:06:27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:109,030,465-109,075,773)mRNA (may differ from genome)Protein (475 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SCMC1_MOUSE
DESCRIPTION: RecName: Full=Calcium-binding mitochondrial carrier protein SCaMC-1; AltName: Full=Small calcium-binding mitochondrial carrier protein 1; AltName: Full=Solute carrier family 25 member 24;
FUNCTION: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 4 EF-hand domains.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.0056-0.214 Picture PostScript Text
3' UTR -463.801947-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR002167 - Graves_DC
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on Q8BMD8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
      
      
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005347 ATP transmembrane transporter activity
GO:0005509 calcium ion binding
GO:0015217 ADP transmembrane transporter activity
GO:0046872 metal ion binding

Biological Process:
GO:0006839 mitochondrial transport
GO:0010941 regulation of cell death
GO:0015866 ADP transport
GO:0015867 ATP transport
GO:0034599 cellular response to oxidative stress
GO:0055085 transmembrane transport
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK032806 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720455K09 product:PEROXISOMAL CA-DEPENDENT SOLUTE CARRIER homolog [Oryctolagus cuniculus], full insert sequence.
AK146034 - Mus musculus 15 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530025F19 product:Peroxisomal CA-dependent solute carrier homolog, full insert sequence.
AK170598 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630109N12 product:Peroxisomal CA-dependent solute carrier homolog, full insert sequence.
AK167778 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730022M06 product:Peroxisomal CA-dependent solute carrier homolog, full insert sequence.
AK168090 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730057C11 product:Peroxisomal CA-dependent solute carrier homolog, full insert sequence.
BC055369 - Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24, mRNA (cDNA clone MGC:60830 IMAGE:30055307), complete cds.
AK187917 - Mus musculus cDNA, clone:Y0G0143H14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000029477, based on BLAT search.
BC022637 - Mus musculus solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24, mRNA (cDNA clone IMAGE:4208509), partial cds.
AK011425 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610016M12 product:inferred: peroxisomal Ca-dependent solute carrier {Oryctolagus cuniculus}, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENSMUST00000029477.1, ENSMUST00000029477.10, ENSMUST00000029477.2, ENSMUST00000029477.3, ENSMUST00000029477.4, ENSMUST00000029477.5, ENSMUST00000029477.6, ENSMUST00000029477.7, ENSMUST00000029477.8, ENSMUST00000029477.9, NM_172685, Q3TCQ2, Q3THY3, Q7TPC2, Q8BMD8, Scamc1, SCMC1_MOUSE, uc008rae.1, uc008rae.2, uc008rae.3
UCSC ID: ENSMUST00000029477.11
RefSeq Accession: NM_172685
Protein: Q8BMD8 (aka SCMC1_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.