Mouse Gene Slc25a42 (ENSMUST00000110127.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25, member 42 (Slc25a42), mRNA. (from RefSeq NM_001007570)
Gencode Transcript: ENSMUST00000110127.7
Gencode Gene: ENSMUSG00000002346.16
Transcript (Including UTRs)
   Position: mm10 chr8:70,184,340-70,212,305 Size: 27,966 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr8:70,186,469-70,194,204 Size: 7,736 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:70,184,340-70,212,305)mRNA (may differ from genome)Protein (318 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: S2542_MOUSE
DESCRIPTION: RecName: Full=Mitochondrial coenzyme A transporter SLC25A42; AltName: Full=Solute carrier family 25 member 42;
FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'- diphosphate (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.00110-0.509 Picture PostScript Text
3' UTR -736.202129-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014762 - DNA_mismatch_repair_CS
IPR002167 - Graves_DC
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8R0Y8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005347 ATP transmembrane transporter activity
GO:0015217 ADP transmembrane transporter activity
GO:0015228 coenzyme A transmembrane transporter activity
GO:0043262 adenosine-diphosphatase activity
GO:0080122 AMP transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0015866 ADP transport
GO:0015867 ATP transport
GO:0035349 coenzyme A transmembrane transport
GO:0055085 transmembrane transport
GO:0080121 AMP transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK143301 - Mus musculus 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230039B19 product:hypothetical Mitochondrial carrier protein/Mitochondrial substrate carrier containing protein, full insert sequence.
BC025937 - Mus musculus solute carrier family 25, member 42, mRNA (cDNA clone MGC:37808 IMAGE:5098192), complete cds.
BC036140 - Mus musculus solute carrier family 25, member 42, mRNA (cDNA clone MGC:37251 IMAGE:4972835), complete cds.
BC022213 - Mus musculus solute carrier family 25, member 42, mRNA (cDNA clone IMAGE:5137229).
AK165793 - Mus musculus 15 days embryo brain cDNA, RIKEN full-length enriched library, clone:G630076L14 product:hypothetical Mitochondrial carrier protein/Mitochondrial substrate carrier containing protein, full insert sequence.
AK013820 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900084M01 product:unclassifiable, full insert sequence.
AK049593 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430048N08 product:hypothetical protein, full insert sequence.
AK165460 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530008G02 product:unclassifiable, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001007570, Q8R0Y8, S2542_MOUSE, uc012gex.1, uc012gex.2
UCSC ID: uc012gex.2
RefSeq Accession: NM_001007570
Protein: Q8R0Y8 (aka S2542_MOUSE)
CCDS: CCDS40370.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.