ID:GHC2_MOUSE DESCRIPTION: RecName: Full=Mitochondrial glutamate carrier 2; Short=GC-2; AltName: Full=Glutamate/H(+) symporter 2; AltName: Full=Solute carrier family 25 member 18; FUNCTION: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9DB41
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC116828 - Mus musculus solute carrier family 25 (mitochondrial carrier), member 18, mRNA (cDNA clone MGC:151205 IMAGE:40126147), complete cds. BC137603 - Mus musculus solute carrier family 25 (mitochondrial carrier), member 18, mRNA (cDNA clone MGC:169227 IMAGE:8860622), complete cds. AK005250 - Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500015I14 product:solute carrier family 25, (mitochondrial carrier), member 18, full insert sequence.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9DB41 (Reactome details) participates in the following event(s):
R-MMU-8875623 SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix R-MMU-428643 Organic anion transporters R-MMU-425374 Amino acid and oligopeptide SLC transporters R-MMU-425393 Metabolism of nitrogenous molecules R-MMU-425407 SLC-mediated transmembrane transport R-MMU-382551 Transport of small molecules
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