Mouse Gene Mtch2 (ENSMUST00000136872.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus mitochondrial carrier 2 (Mtch2), transcript variant 1, mRNA. (from RefSeq NM_019758) RefSeq Summary (NM_001317241): This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]. Gencode Transcript: ENSMUST00000136872.7 Gencode Gene: ENSMUSG00000027282.17 Transcript (Including UTRs) Position: mm10 chr2:90,847,155-90,866,810 Size: 19,656 Total Exon Count: 13 Strand: + Coding Region Position: mm10 chr2:90,847,299-90,865,270 Size: 17,972 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q791V5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006089 lactate metabolic process GO:0010917 negative regulation of mitochondrial membrane potential GO:0035701 hematopoietic stem cell migration GO:0042775 mitochondrial ATP synthesis coupled electron transport GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045820 negative regulation of glycolytic process GO:0061484 hematopoietic stem cell homeostasis GO:0070585 protein localization to mitochondrion GO:0071478 cellular response to radiation GO:0090152 establishment of protein localization to mitochondrial membrane involved in mitochondrial fission GO:0097284 hepatocyte apoptotic process GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
US Server
