Mouse Gene Slc25a1 (ENSMUST00000003622.15) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 (Slc25a1), mRNA. (from RefSeq NM_153150)
Gencode Transcript: ENSMUST00000003622.15
Gencode Gene: ENSMUSG00000003528.15
Transcript (Including UTRs)
   Position: mm10 chr16:17,925,223-17,928,219 Size: 2,997 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr16:17,925,813-17,928,079 Size: 2,267 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:17,925,223-17,928,219)mRNA (may differ from genome)Protein (311 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q8JZU2_MOUSE
DESCRIPTION: SubName: Full=Protein Slc25a1; SubName: Full=Solute carrier family 25 (Mitochondrial carrier, citrate transporter), member 1;
SIMILARITY: Belongs to the mitochondrial carrier family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.50140-0.389 Picture PostScript Text
3' UTR -212.80590-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q8JZU2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015137 citrate transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0006843 mitochondrial citrate transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF200633 - JP 2014500723-A/8136: Polycomb-Associated Non-Coding RNAs.
BC037087 - Mus musculus solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1, mRNA (cDNA clone MGC:47055 IMAGE:5124403), complete cds.
AK005070 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300019P08 product:TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL PRECURSOR (CITRATE TRANSPORT PROTEIN) (CTP) (TRICARBOXYLATE CARRIER PROTEIN) homolog [Rattus norvegicus], full insert sequence.
AK170191 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630026H16 product:solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1, full insert sequence.
AK178581 - Mus musculus cDNA, clone:Y0G0107E02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
AK159289 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420014L14 product:solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1, full insert sequence.
LF247299 - JP 2014500723-A/54802: Polycomb-Associated Non-Coding RNAs.
LF247300 - JP 2014500723-A/54803: Polycomb-Associated Non-Coding RNAs.
AK188281 - Mus musculus cDNA, clone:Y0G0144K15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
AK206906 - Mus musculus cDNA, clone:Y2G0106F05, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
AK211700 - Mus musculus cDNA, clone:Y2G0122J08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
AK219123 - Mus musculus cDNA, clone:Y2G0147H02, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
LF247301 - JP 2014500723-A/54804: Polycomb-Associated Non-Coding RNAs.
LF247302 - JP 2014500723-A/54805: Polycomb-Associated Non-Coding RNAs.
AK177500 - Mus musculus cDNA, clone:Y0G0102P05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
AK185953 - Mus musculus cDNA, clone:Y0G0135M11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000003622, based on BLAT search.
LF247303 - JP 2014500723-A/54806: Polycomb-Associated Non-Coding RNAs.
LF247304 - JP 2014500723-A/54807: Polycomb-Associated Non-Coding RNAs.
MA436210 - JP 2018138019-A/8136: Polycomb-Associated Non-Coding RNAs.
MA482876 - JP 2018138019-A/54802: Polycomb-Associated Non-Coding RNAs.
MA482877 - JP 2018138019-A/54803: Polycomb-Associated Non-Coding RNAs.
MA482878 - JP 2018138019-A/54804: Polycomb-Associated Non-Coding RNAs.
MA482879 - JP 2018138019-A/54805: Polycomb-Associated Non-Coding RNAs.
MA482880 - JP 2018138019-A/54806: Polycomb-Associated Non-Coding RNAs.
MA482881 - JP 2018138019-A/54807: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
m_malatexPathway - Shuttle for transfer of acetyl groups from mitochondria to the cytosol

Reactome (by CSHL, EBI, and GO)

Protein Q8JZU2 (Reactome details) participates in the following event(s):

R-MMU-75849 Transport of Citrate from Mitochondrial Matrix to cytosol
R-MMU-372449 phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]
R-MMU-75105 Fatty acyl-CoA biosynthesis
R-MMU-70263 Gluconeogenesis
R-MMU-8978868 Fatty acid metabolism
R-MMU-70326 Glucose metabolism
R-MMU-556833 Metabolism of lipids
R-MMU-71387 Metabolism of carbohydrates
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_131850, NM_153150, Q8JZU2, Q8JZU2_MOUSE, uc007ymp.1, uc007ymp.2, uc007ymp.3
UCSC ID: uc007ymp.3
RefSeq Accession: NM_153150
Protein: Q8JZU2 CCDS: CCDS28014.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.