ID:M2OM_MOUSE DESCRIPTION: RecName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein; Short=OGCP; AltName: Full=Solute carrier family 25 member 11; FUNCTION: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9CR62
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK206341 - Mus musculus cDNA, clone:Y2G0104I15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. BC019631 - Mus musculus solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:18695 IMAGE:4023179), complete cds. AK212009 - Mus musculus cDNA, clone:Y2G0123J05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK009487 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310022P18 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence. AK210712 - Mus musculus cDNA, clone:Y2G0119F12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK214004 - Mus musculus cDNA, clone:Y2G0130E14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. BC003455 - Mus musculus solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:6807 IMAGE:2648336), complete cds. AK003957 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110029F22 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence. AK009824 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310045L02 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence. AK168951 - Mus musculus 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920067A19 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence. AK178451 - Mus musculus cDNA, clone:Y0G0106M07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK213339 - Mus musculus cDNA, clone:Y2G0128A13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK193464 - Mus musculus cDNA, clone:Y1G0112G02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK197579 - Mus musculus cDNA, clone:Y1G0125I06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK199871 - Mus musculus cDNA, clone:Y1G0132K08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK202008 - Mus musculus cDNA, clone:Y1G0140B12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK213174 - Mus musculus cDNA, clone:Y2G0127G20, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK207630 - Mus musculus cDNA, clone:Y2G0108J23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK212146 - Mus musculus cDNA, clone:Y2G0124A05, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK183372 - Mus musculus cDNA, clone:Y0G0125K17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK187524 - Mus musculus cDNA, clone:Y0G0142C17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK181540 - Mus musculus cDNA, clone:Y0G0118I05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK215545 - Mus musculus cDNA, clone:Y2G0135G08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK213879 - Mus musculus cDNA, clone:Y2G0129M24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK202646 - Mus musculus cDNA, clone:Y1G0142E13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search. AK186207 - Mus musculus cDNA, clone:Y0G0136J22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project m_malatePathway - Malate-aspartate shuttle m_malatexPathway - Shuttle for transfer of acetyl groups from mitochondria to the cytosol
Reactome (by CSHL, EBI, and GO)
Protein Q9CR62 (Reactome details) participates in the following event(s):
R-MMU-198440 malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] R-MMU-376851 Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane R-MMU-70263 Gluconeogenesis R-MMU-70326 Glucose metabolism R-MMU-71387 Metabolism of carbohydrates R-MMU-1430728 Metabolism