Mouse Gene Slc25a11 (ENSMUST00000014750.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 (Slc25a11), mRNA. (from RefSeq NM_024211)
Gencode Transcript: ENSMUST00000014750.14
Gencode Gene: ENSMUSG00000014606.14
Transcript (Including UTRs)
   Position: mm10 chr11:70,644,196-70,647,058 Size: 2,863 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr11:70,644,766-70,646,862 Size: 2,097 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:70,644,196-70,647,058)mRNA (may differ from genome)Protein (314 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: M2OM_MOUSE
DESCRIPTION: RecName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein; Short=OGCP; AltName: Full=Solute carrier family 25 member 11;
FUNCTION: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.10196-0.475 Picture PostScript Text
3' UTR -172.00570-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q9CR62
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0015367 oxoglutarate:malate antiporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0015742 alpha-ketoglutarate transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK206341 - Mus musculus cDNA, clone:Y2G0104I15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
BC019631 - Mus musculus solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:18695 IMAGE:4023179), complete cds.
AK212009 - Mus musculus cDNA, clone:Y2G0123J05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK009487 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310022P18 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence.
AK210712 - Mus musculus cDNA, clone:Y2G0119F12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK214004 - Mus musculus cDNA, clone:Y2G0130E14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
BC003455 - Mus musculus solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11, mRNA (cDNA clone MGC:6807 IMAGE:2648336), complete cds.
AK003957 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110029F22 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence.
AK009824 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310045L02 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence.
AK168951 - Mus musculus 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920067A19 product:solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11, full insert sequence.
AK178451 - Mus musculus cDNA, clone:Y0G0106M07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK213339 - Mus musculus cDNA, clone:Y2G0128A13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK193464 - Mus musculus cDNA, clone:Y1G0112G02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK197579 - Mus musculus cDNA, clone:Y1G0125I06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK199871 - Mus musculus cDNA, clone:Y1G0132K08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK202008 - Mus musculus cDNA, clone:Y1G0140B12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK213174 - Mus musculus cDNA, clone:Y2G0127G20, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK207630 - Mus musculus cDNA, clone:Y2G0108J23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK212146 - Mus musculus cDNA, clone:Y2G0124A05, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK183372 - Mus musculus cDNA, clone:Y0G0125K17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK187524 - Mus musculus cDNA, clone:Y0G0142C17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK181540 - Mus musculus cDNA, clone:Y0G0118I05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK215545 - Mus musculus cDNA, clone:Y2G0135G08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK213879 - Mus musculus cDNA, clone:Y2G0129M24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK202646 - Mus musculus cDNA, clone:Y1G0142E13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.
AK186207 - Mus musculus cDNA, clone:Y0G0136J22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014750, based on BLAT search.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
m_malatePathway - Malate-aspartate shuttle
m_malatexPathway - Shuttle for transfer of acetyl groups from mitochondria to the cytosol

Reactome (by CSHL, EBI, and GO)

Protein Q9CR62 (Reactome details) participates in the following event(s):

R-MMU-198440 malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]
R-MMU-376851 Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane
R-MMU-70263 Gluconeogenesis
R-MMU-70326 Glucose metabolism
R-MMU-71387 Metabolism of carbohydrates
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: M2OM_MOUSE, NM_024211, Q9CR62, uc007jvr.1, uc007jvr.2, uc007jvr.3, uc007jvr.4
UCSC ID: uc007jvr.4
RefSeq Accession: NM_024211
Protein: Q9CR62 (aka M2OM_MOUSE)
CCDS: CCDS24958.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.