ID:MFRN1_MOUSE DESCRIPTION: RecName: Full=Mitoferrin-1; AltName: Full=Mitochondrial iron transporter 1; AltName: Full=Mitochondrial solute carrier protein; AltName: Full=Solute carrier family 25 member 37; FUNCTION: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen. DEVELOPMENTAL STAGE: In the developing embryo, it is first detected at embryonic day 7.5 (E7.5) in the extraembryonic yolk sac, coincident with the appearance of blood islands. Later, restricted expression is seen in E14.5 fetal liver, the primary source of erythrocyte production in mid-gestation. Expression decreases in the spleen around 4-5 weeks of age, suggesting that it is decreased during splenic lymphocyte maturation. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats. SEQUENCE CAUTION: Sequence=BAB29978.1; Type=Erroneous initiation; Sequence=BAC25649.1; Type=Frameshift; Positions=141, 196;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q920G8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005381 iron ion transmembrane transporter activity GO:0015093 ferrous iron transmembrane transporter activity
Biological Process: GO:0006811 ion transport GO:0006839 mitochondrial transport GO:0048250 mitochondrial iron ion transport GO:0055072 iron ion homeostasis GO:1903874 ferrous iron transmembrane transport