Mouse Gene Slc25a47 (ENSMUST00000057026.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus solute carrier family 25, member 47 (Slc25a47), mRNA. (from RefSeq NM_001012310)
Gencode Transcript: ENSMUST00000057026.9
Gencode Gene: ENSMUSG00000048856.9
Transcript (Including UTRs)
Position: mm10 chr12:108,851,129-108,856,815 Size: 5,687 Total Exon Count: 6 Strand: +
Coding Region
Position: mm10 chr12:108,851,180-108,856,219 Size: 5,040 Coding Exon Count: 6
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: S2547_MOUSE
DESCRIPTION: RecName: Full=Solute carrier family 25 member 47; AltName: Full=Hepatocellular carcinoma down-regulated mitochondrial carrier homolog;
FUNCTION: Uncoupling protein which may catalyze the physiological 'proton leak' in liver (By similarity).SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).SIMILARITY: Belongs to the mitochondrial carrier family.SIMILARITY: Contains 3 Solcar repeats.SEQUENCE CAUTION: Sequence=AAH55027.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D013749
Tetrachlorodibenzodioxin
C028474
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
C038890
2,3,4,7,8-pentachlorodibenzofuran
C014211
2,3,7,8-tetrachlorodibenzofuran
C028451
3,4,3',4'-tetrachlorobiphenyl
D000082
Acetaminophen
D000111
Acetylcysteine
D016604
Aflatoxin B1
D001564
Benzo(a)pyrene
D002994
Clofibrate
more ... click here to view the complete list
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom
Pfam Domains: PF00153 - Mitochondrial carrier protein
SCOP Domains: 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
103506 - Mitochondrial carrier
ModBase Predicted Comparative 3D Structure on Q6IS41
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK149369 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730001O18 product:Human full-length cDNA clone CS0DM005YJ11 of fetal liver of Homo sapiens (Human) (Fragment) homolog [Homo sapiens], full insert sequence.BC089616 - Mus musculus expressed sequence AI132487, mRNA (cDNA clone MGC:107675 IMAGE:6760348), complete cds.BC055027 - Mus musculus expressed sequence AI132487, mRNA (cDNA clone IMAGE:5132323), partial cds.BC035527 - Mus musculus expressed sequence AI132487, mRNA (cDNA clone IMAGE:5125899), with apparent retained intron.BC069939 - Mus musculus expressed sequence AI132487, mRNA (cDNA clone MGC:78238 IMAGE:5053384), complete cds.BC042739 - Mus musculus expressed sequence AI132487, mRNA (cDNA clone IMAGE:4236520), **** WARNING: chimeric clone ****.
Other Names for This Gene
Alternate Gene Symbols: Hdmcp, NM_001012310, Q3UES2, Q5FW58, Q6IS41, Q7TPP3, S2547_MOUSE, uc007pae.1UCSC ID: uc007pae.1RefSeq Accession: NM_001012310
Protein: Q6IS41
(aka S2547_MOUSE)
CCDS: CCDS26165.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.