Mouse Gene Bmx (ENSMUST00000112265.9) from GENCODE VM33
  Description: Mus musculus BMX non-receptor tyrosine kinase (Bmx), mRNA. (from RefSeq NM_009759)
Gencode Transcript: ENSMUST00000112265.9
Gencode Gene: ENSMUSG00000031377.12
Transcript (Including UTRs)
   Position: mm39 chrX:162,975,838-163,041,189 Size: 65,352 Total Exon Count: 19 Strand: -
Coding Region
   Position: mm39 chrX:162,976,732-163,041,046 Size: 64,315 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-15 19:06:27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:162,975,838-163,041,189)mRNA (may differ from genome)Protein (655 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: B1AUL6_MOUSE
DESCRIPTION: SubName: Full=BMX non-receptor tyrosine kinase; SubName: Full=Cytoplasmic tyrosine-protein kinase BMX;
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.00143-0.308 Picture PostScript Text
3' UTR -233.40894-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR000980 - SH2
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR001562 - Znf_Btk_motif

Pfam Domains:
PF00779 - BTK motif
PF00169 - PH domain
PF07714 - Protein tyrosine kinase
PF00017 - SH2 domain

ModBase Predicted Comparative 3D Structure on B1AUL6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation

Cellular Component:
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0032587 ruffle membrane


-  Descriptions from all associated GenBank mRNAs
  AK036707 - Mus musculus adult male bone cDNA, RIKEN full-length enriched library, clone:9830165F06 product:BMX non-receptor tyrosine kinase, full insert sequence.
AK040936 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530048A03 product:BMX non-receptor tyrosine kinase, full insert sequence.
U88091 - Mus musculus protein tyrosine kinase Bmx mRNA, complete cds.
BC138104 - Mus musculus BMX non-receptor tyrosine kinase, mRNA (cDNA clone MGC:169728 IMAGE:8861123), complete cds.
BC138105 - Mus musculus BMX non-receptor tyrosine kinase, mRNA (cDNA clone MGC:169729 IMAGE:8861124), complete cds.
AF012104 - Mus musculus cytoplasmic tyrosine kinase (bmx) mRNA, complete cds.
AK080038 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530051M20 product:BMX non-receptor tyrosine kinase, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B1AUL6, B1AUL6_MOUSE, ENSMUST00000112265.1, ENSMUST00000112265.2, ENSMUST00000112265.3, ENSMUST00000112265.4, ENSMUST00000112265.5, ENSMUST00000112265.6, ENSMUST00000112265.7, ENSMUST00000112265.8, NM_009759, RP23-330O24.2-001, uc009uvj.1, uc009uvj.2, uc009uvj.3
UCSC ID: ENSMUST00000112265.9
RefSeq Accession: NM_009759
Protein: B1AUL6

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.