Trends Cardiovasc Med 1999,
PMID: 10881752
Mehta, K D; Miller, L
We have recently shown that different signal transduction pathways initiated by a variety of agents converge on growth-responsive p42/44MAPK signaling cascade to induce low-density lipoprotein (LDL) receptor expression. Our recent demonstration that stress-activated p38MAPK negatively regulates LDL receptor expression in an isoform-specific manner via modulation of p42/44MAPK cascade represents a new dimension of complexity in the molecular communication that governs LDL receptor expression. The suggested one-way communication between p38MAPK and p42/44MAPK provides a potential mechanism for fine-tuning cellular levels of cholesterol in response to a diverse set of environmental cues, including stress. Cross talk between MAPKs opens new avenues toward understanding a variety of pathogenic processes; this makes them tempting targets for therapeutic interventions in cardiovascular diseases.
Diseases/Pathways annotated by Medline MESH: Hypercholesterolemia
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Text Mining Data
p38 ⊣ low-density lipoprotein receptor: "
Inhibition of stress activated
p38 mitogen activated protein kinase
induces low-density lipoprotein receptor expression
"
LDL receptor → p38MAPK: "
Our recent demonstration that stress activated p38MAPK negatively regulates LDL receptor expression in an isoform-specific manner via modulation of p42/44MAPK cascade represents a new dimension of complexity in the molecular communication that governs LDL receptor expression
"
LDL receptor → p38MAPK: "
Our recent demonstration that stress activated p38MAPK negatively regulates LDL receptor expression in an isoform-specific manner via modulation of p42/44MAPK cascade represents a new dimension of complexity in the molecular communication that governs LDL receptor expression
"
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