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mitogen activated protein ( MAP ) kinase → tumour necrosis factor-alpha (TNF-alpha): " 1. We have previously shown that tumour necrosis factor-alpha (TNF-alpha) activates p38 mitogen activated protein ( MAP ) kinase to produce interleukin-8 (IL-8) by human pulmonary vascular endothelial cells "
p38 → TNF-alpha: " However, the effect of N-acetylcysteine (NAC), which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined "
IL-8 → TNF-alpha: " However, the effect of N-acetylcysteine (NAC), which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined "
p38 — N-acetylcysteine (NAC): " However, the effect of N-acetylcysteine (NAC) , which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined "
IL-8 — N-acetylcysteine (NAC): " However, the effect of N-acetylcysteine (NAC) , which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined "
IL-8 → NAC: " To clarify these issues, we examined the effect of NAC on TNF-alpha induced activation of p38 MAP kinase, MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase, and p38 MAP kinase mediated IL-8 production "
MAP kinase kinase (MKK) 3 → TNF-alpha: " To clarify these issues, we examined the effect of NAC on TNF-alpha induced activation of p38 MAP kinase, MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase, and p38 MAP kinase mediated IL-8 production "
MAP kinase kinase (MKK) 3 — NAC: " To clarify these issues, we examined the effect of NAC on TNF-alpha induced activation of p38 MAP kinase, MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase, and p38 MAP kinase mediated IL-8 production "
p38 → TNF-alpha: " 6. These results indicate that the cellular reduction and oxidation ( redox ) regulated by intracellular GSH is critical for TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells, and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury "
IL-8 → TNF-alpha: " 6. These results indicate that the cellular reduction and oxidation ( redox ) regulated by intracellular GSH is critical for TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells, and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury "