Gene interactions and pathways from curated databases and text-mining
Endocr J 2001, PMID: 11456275

TNF-alpha inhibits 3T3-L1 adipocyte differentiation without downregulating the expression of C/EBPbeta and delta.

Kurebayashi, S; Sumitani, S; Kasayama, S; Jetten, A M; Hirose, T

Tumor necrosis factor-alpha (TNF-alpha) has been reported to inhibit adipocyte differentiation in which multiple transcription factors including CCAAT enhancer binding proteins (C/EBPs) and peroxisome proliferator-activated receptor (PPAR) gamma play an important role. Induction of C/EBPalpha and PPARgamma, which regulate the expression of many adipocyte-related genes, is dependent on the expression of C/EBPbeta and C/EBPdelta at the early phase of adipocyte differentiation. To elucidate the mechanism by which TNF-alpha inhibits adipocyte differentiation, we examined the effect of TNF-alpha on the expression of these transcription factors in mouse 3T3-L1 preadipocytes. TNF-alpha did not abrogate the induction of C/EBPbeta and C/EBPdelta in response to differentiation stimuli. In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma. Our results suggest that TNF-alpha inhibits adipocyte differentiation independently of the downregulation of C/EBPbeta and C/EBPdelta.

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Text Mining Data

C/EBPalpha → C/EBPbeta: " Induction of C/EBPalpha and PPARgamma, which regulate the expression of many adipocyte related genes, is dependent on the expression of C/EBPbeta and C/EBPdelta at the early phase of adipocyte differentiation "

C/EBPalpha → C/EBPdelta: " Induction of C/EBPalpha and PPARgamma, which regulate the expression of many adipocyte related genes, is dependent on the expression of C/EBPbeta and C/EBPdelta at the early phase of adipocyte differentiation "

PPARgamma → C/EBPbeta: " Induction of C/EBPalpha and PPARgamma , which regulate the expression of many adipocyte related genes, is dependent on the expression of C/EBPbeta and C/EBPdelta at the early phase of adipocyte differentiation "

PPARgamma → C/EBPdelta: " Induction of C/EBPalpha and PPARgamma , which regulate the expression of many adipocyte related genes, is dependent on the expression of C/EBPbeta and C/EBPdelta at the early phase of adipocyte differentiation "

TNF-alpha ⊣ C/EBPalpha: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma "

TNF-alpha ⊣ PPARgamma: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma "

C/EBPbeta ⊣ C/EBPalpha: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma "

C/EBPbeta ⊣ PPARgamma: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma "

C/EBPdelta ⊣ C/EBPalpha: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta , whereas it downregulated the expression of C/EBPalpha and PPARgamma "

C/EBPdelta ⊣ PPARgamma: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta , whereas it downregulated the expression of C/EBPalpha and PPARgamma "

TNF-alpha → C/EBPbeta: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta, whereas it downregulated the expression of C/EBPalpha and PPARgamma "

TNF-alpha → C/EBPdelta: " In fully differentiated adipocytes, TNF-alpha rapidly induced C/EBPbeta and C/EBPdelta , whereas it downregulated the expression of C/EBPalpha and PPARgamma "

Manually curated Databases

No curated data.