Biochim Biophys Acta 2002,
PMID: 11781145
Beppu, Mahiro; Ikebe, Tetsuro; Shirasuna, Kanemitsu
Matrix metalloproteinase-9 (MMP-9) produced by tumor cells is known to be implicated in the invasion of squamous cell carcinoma (SCC). In the process of searching for agents to inhibit MMP-9 in cancer, immunosuppressive factors, dexamethasone (DEX) and interleukin-4 (IL-4) were found to inhibit protein production as well as gene expression of MMP-9 in tumor necrosis factor alpha (TNFalpha)-stimulated SCC cells. DEX and IL-4 could also suppress the expression of urokinase type plasminogen activator (uPA) to prevent the conversion from the proenzyme form of MMP-9 to its active form. Regarding their mechanisms to inhibit the expression of MMP-9 and uPA, DEX and IL-4 had no effect on the cell surface levels of TNFalpha receptors, but inhibited the activation of NF-kappaB and NF-kappaB-dependent gene expression. DEX, but not IL-4, could strongly augment the TNFalpha-induced expression of IkappaBalpha in SCC cells. These results suggest that DEX and IL-4 suppress not only immunological reactions, but also tumor invasion by targeting NF-kappaB.
Diseases/Pathways annotated by Medline MESH: Carcinoma, Squamous Cell, Mouth Neoplasms
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Text Mining Data
MMP-9 ⊣ interleukin-4 (IL-4): "
In the process of searching for agents to inhibit MMP-9 in cancer, immunosuppressive factors, dexamethasone ( DEX ) and
interleukin-4 (IL-4) were found to
inhibit protein production as well as gene expression of
MMP-9 in tumor necrosis factor alpha (TNFalpha) stimulated SCC cells
"
SCC → tumor necrosis factor alpha (TNFalpha): "
In the process of searching for agents to inhibit MMP-9 in cancer, immunosuppressive factors, dexamethasone ( DEX ) and interleukin-4 (IL-4) were found to inhibit protein production as well as gene expression of MMP-9 in tumor necrosis factor alpha (TNFalpha) stimulated SCC cells
"
NF-kappaB ⊣ IL-4: "
Regarding their mechanisms to inhibit the expression of MMP-9 and uPA, DEX and IL-4 had no effect on the cell surface levels of TNFalpha receptors, but inhibited the activation of NF-kappaB and NF-kappaB dependent gene expression
"
IkappaBalpha → TNFalpha: "
DEX, but not IL-4, could strongly augment the TNFalpha induced expression of IkappaBalpha in SCC cells
"
IkappaBalpha → IL-4: "
DEX, but not IL-4 , could strongly augment the TNFalpha induced expression of IkappaBalpha in SCC cells
"
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