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Gene interactions and pathways from curated databases and text-mining
Curr Med Chem 2002, PMID: 11860356

Inhibitors of AP-1 and NF-kappa B mediated transcriptional activation: therapeutic potential in autoimmune diseases and structural diversity.

Palanki, Moorthy S S

Cytokines and chemokines play a very important role in a number of inflammatory diseases. In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells (NFAT) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8, IL-13, TNF alpha, and GM-CSF. During the last few years, several groups have developed inhibitors of AP-1, NF-kappa B or both, and NFAT. This review article presents the recent progress in the development of inhibitors for AP-1, NF-kappa B, and NFAT mediated transcriptional activation.

Diseases/Pathways annotated by Medline MESH: Autoimmune Diseases
Document information provided by NCBI PubMed

Text Mining Data

TNF alpha → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8, IL-13, TNF alpha , and GM-CSF "

GM-CSF → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8, IL-13, TNF alpha, and GM-CSF "

IL-13 → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8, IL-13 , TNF alpha, and GM-CSF "

IL-2 → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2 , IL-3, IL-4, IL-5, IL-8, IL-13, TNF alpha, and GM-CSF "

IL-3 → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3 , IL-4, IL-5, IL-8, IL-13, TNF alpha, and GM-CSF "

IL-4 → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4 , IL-5, IL-8, IL-13, TNF alpha, and GM-CSF "

IL-5 → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5 , IL-8, IL-13, TNF alpha, and GM-CSF "

IL-8 → nuclear factor kappa B (NF-kappa B): " In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8 , IL-13, TNF alpha, and GM-CSF "

Manually curated Databases

No curated data.