Gene interactions and pathways from curated databases and text-mining
Prostaglandins Leukot Essent Fatty Acids 2002, PMID: 12054913

Interleukin (IL)-17 enhances prostaglandin F(2 alpha)-stimulated IL-6 synthesis in osteoblasts.

Tokuda, H; Kozawa, O; Uematsu, T

We previously showed that prostaglandin F(2alpha) (PGF(2alpha)) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells. It has recently been reported that tumor necrosis factor-alpha-induced IL-6 synthesis is amplified by IL-17 in these cells. In the present study, we investigated the effect of IL-17 on the IL-6 synthesis stimulated by PGF(2alpha) in MC3T3-E1 cells. IL-17 significantly enhanced the PGF(2alpha)-induced IL-6 synthesis in a dose-dependent manner in the range between 0.1 and 10 ng/ml. IL-17 also enhanced the IL-6 synthesis stimulated by 12- O -tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C. In addition, IL-17 amplified the IL-6 synthesis induced by ET-1. However, IL-17 hardly affected the phosphorylation of p44/p42 MAP kinase induced by PGF(2alpha) or ET-1. These results strongly suggest that IL-17 enhances the IL-6 synthesis stimulated by PGF(2alpha) as well as ET-1 in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase.

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Text Mining Data

IL-6 → Interleukin (IL)-17: " Interleukin (IL)-17 enhances prostaglandin F ( 2 alpha ) -stimulated IL-6 synthesis in osteoblasts "

mitogen activated protein ( MAP ) kinase → endothelin-1 (ET-1): " We previously showed that prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells "

mitogen activated protein ( MAP ) kinase → interleukin (IL)-6: " We previously showed that prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells "

endothelin-1 (ET-1) → interleukin (IL)-6: " We previously showed that prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells "

IL-6 → tumor necrosis factor-alpha: " It has recently been reported that tumor necrosis factor-alpha induced IL-6 synthesis is amplified by IL-17 in these cells "

IL-6 — IL-17: " In the present study, we investigated the effect of IL-17 on the IL-6 synthesis stimulated by PGF ( 2alpha ) in MC3T3-E1 cells "

IL-6 → IL-17: " These results strongly suggest that IL-17 enhances the IL-6 synthesis stimulated by PGF ( 2alpha ) as well as ET-1 in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase "

Manually curated Databases

No curated data.