FEBS Lett 2004,
PMID: 15251452
Mueller, Anja; Strange, Philip G
The interaction of the chemokine receptor, CCR5, expressed in recombinant cells, with different G proteins was investigated and CCR5 was found to interact with Gi, Go and Gq species. Interaction with Gi leads to G protein activation, whereas Gq does not seem to be activated. Additionally, CCR5 activation also leads to phosphorylation of Janus kinase 2 (JAK2). Activation of JAK2 is independent of Gi or Gq activation. Gi protein activation was not prevented by inhibition of JAK, showing that heterotrimeric G protein activation and activation of the JAK/signal transducer and activator of transcription (STAT) pathway are independent of each other.
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Text Mining Data
Janus kinase 2 (JAK2) → CCL3: "
CCL3 , acting via the chemokine receptor CCR5,
leads to independent activation of
Janus kinase 2 (JAK2) and Gi proteins
"
Janus kinase 2 (JAK2) → CCR5: "
Additionally, CCR5 activation also leads to phosphorylation of Janus kinase 2 (JAK2)
"
Manually curated Databases
-
IRef Hprd Interaction:
GNAI2
—
CCR5
(in vivo)
-
IRef Hprd Interaction:
GNAI3
—
CCR5
(in vivo)
-
IRef Hprd Interaction:
CCR5
—
GNAI1
(in vivo)
-
IRef Hprd Interaction:
CCR5
—
GNAO1
(in vivo)
-
IRef Hprd Interaction:
GNAQ
—
CCR5
(in vivo)
-
IRef Intact Interaction:
GNAI2
—
CXCR5
(physical association, coimmunoprecipitation)
-
IRef Intact Interaction:
GNAI2
—
CXCR5
(phosphorylation reaction, experimental interaction detection)
-
IRef Intact Interaction:
CXCR5
—
GNAO1
(physical association, coimmunoprecipitation)
-
IRef Intact Interaction:
GNAQ
—
CXCR5
(physical association, coimmunoprecipitation)
In total, 8 gene pairs are associated to this article in curated databases