Gene interactions and pathways from curated databases and text-mining
FEBS Lett 2004, PMID: 15251452

CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.

Mueller, Anja; Strange, Philip G

The interaction of the chemokine receptor, CCR5, expressed in recombinant cells, with different G proteins was investigated and CCR5 was found to interact with Gi, Go and Gq species. Interaction with Gi leads to G protein activation, whereas Gq does not seem to be activated. Additionally, CCR5 activation also leads to phosphorylation of Janus kinase 2 (JAK2). Activation of JAK2 is independent of Gi or Gq activation. Gi protein activation was not prevented by inhibition of JAK, showing that heterotrimeric G protein activation and activation of the JAK/signal transducer and activator of transcription (STAT) pathway are independent of each other.

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Text Mining Data

Janus kinase 2 (JAK2) → CCL3: " CCL3 , acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins "

Janus kinase 2 (JAK2) → CCR5: " Additionally, CCR5 activation also leads to phosphorylation of Janus kinase 2 (JAK2) "

Manually curated Databases

  • IRef Hprd Interaction: GNAI2 — CCR5 (in vivo)
  • IRef Hprd Interaction: GNAI3 — CCR5 (in vivo)
  • IRef Hprd Interaction: CCR5 — GNAI1 (in vivo)
  • IRef Hprd Interaction: CCR5 — GNAO1 (in vivo)
  • IRef Hprd Interaction: GNAQ — CCR5 (in vivo)
  • IRef Intact Interaction: GNAI2 — CXCR5 (physical association, coimmunoprecipitation)
  • IRef Intact Interaction: GNAI2 — CXCR5 (phosphorylation reaction, experimental interaction detection)
  • IRef Intact Interaction: CXCR5 — GNAO1 (physical association, coimmunoprecipitation)
  • IRef Intact Interaction: GNAQ — CXCR5 (physical association, coimmunoprecipitation)
In total, 8 gene pairs are associated to this article in curated databases