Gene interactions and pathways from curated databases and text-mining
Nat Immunol 2006, PMID: 16378096

Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.

Wang, Yaya; Tang, Yawei; Teng, Lin; Wu, Yalan; Zhao, Xiaohui; Pei, Gang

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is critical for mediating Toll-like receptor (TLR)-interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity. Here we show that beta-arrestins, a family of multifunctional proteins, directly interacted with TRAF6 after TLR-IL-1R activation. Formation of the beta-arrestin-TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappaB and AP-1. Endotoxin-treated beta-arrestin 2-deficient mice had higher expression of proinflammatory cytokines and were more susceptible to endotoxic shock. Thus, beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling.

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Text Mining Data

receptor-interleukin 1 receptor → TRAF6: " Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling "

-interleukin → AP-1: " Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1 , transcriptional activators of innate immunity "

-interleukin → NF-kappaB: " Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity "

Toll-like receptor ( TLR ) → AP-1: " Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1 , transcriptional activators of innate immunity "

Toll-like receptor ( TLR ) → NF-kappaB: " Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity "

-interleukin 1 receptor (IL-1R) → AP-1: " Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1 , transcriptional activators of innate immunity "

-interleukin 1 receptor (IL-1R) → NF-kappaB: " Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity "

TRAF6 → AP-1: " Formation of the beta-arrestin-TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappaB and AP-1 "

TRAF6 → NF-kappaB: " Formation of the beta-arrestin-TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappaB and AP-1 "

Manually curated Databases

  • IRef Biogrid Interaction: TRAF6 — TRAF6 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ARRB2 — TRAF6 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: UBC — TRAF6 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRAF6 — ARRB1 (physical association, affinity chromatography technology)
  • IRef Innatedb Interaction: ARRB1 — TRAF6 (unknown, -)
In total, 4 gene pairs are associated to this article in curated databases