Gene interactions and pathways from curated databases and text-mining
Immunopharmacol Immunotoxicol 2005, PMID: 16435581

p38 MAPK and NF-kappaB on IL-6 release in human gingival fibroblasts.

Chae, H J; Byun, J O; Chae, S W; Kim, H M; Choi, H I; Pae, H O; Chung, H T; Kim, H R

The induction of interleukin-6 (IL-6) using a proinflammatory cytokine (IL-1beta) was studied in human gingival fibroblasts (HGFs) in relation to p38 MAPK and NF-kappaB transcription factor. When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6, and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor. In addition, the stimulation of IL-6 release also was reduced by the addition of pyrrolidine dithiocarbamate or NF-kappaB SN50, which has been reported as potent NF-kappaB inhibitor. Both the NF-kappaB inhibitors in the presence of SB203580 had more inhibitory effect on IL-6 release. IL-13 stimulated NF-kappaB binding affinity as well as p38 MAP kinase activation, leading to the release of IL-6. However, a specific inhibitor of p38 MAPK, SB203580, had no effect on the NF-kappaB activation, and both the NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the IL-1beta-stimulated HGFs. These results strongly suggest that both p38 MAPK and NF-kappaB are required in IL-1beta-induced IL-6 synthesis and that these two IL-1beta-activated pathways can be primarily dissociated.

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Text Mining Data

IL-6 → IL-1beta: " When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6 , and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor "

IL-6 → IL-1beta: " When added to HGFs, IL-1beta had a stimulatory effect on the production of IL-6 , and this effect was significantly reduced by SB203580, a specific p38 MAPK inhibitor "

IL-6 ⊣ NF-kappaB: " Both the NF-kappaB inhibitors in the presence of SB203580 had more inhibitory effect on IL-6 release "

p38 → IL-13: " IL-13 stimulated NF-kappaB binding affinity as well as p38 MAP kinase activation, leading to the release of IL-6 "

NF-kappaB ⊣ MAPK: " However, a specific inhibitor of p38 MAPK , SB203580, had no effect on the NF-kappaB activation, and both the NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the IL-1beta stimulated HGFs "

IL-6 → IL-1beta: " These results strongly suggest that both p38 MAPK and NF-kappaB are required in IL-1beta induced IL-6 synthesis and that these two IL-1beta activated pathways can be primarily dissociated "

Manually curated Databases

No curated data.