Cell 2006,
PMID: 16530044
Nam, Yunsun; Sliz, Piotr; Song, Luyan; Aster, Jon C; Blacklow, Stephen C
Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.
Document information provided by NCBI PubMed
Text Mining Data
Dashed line = No text mining data
Manually curated Databases
-
MIPS CORUM MAML1-RBP-Jkappa-Notch1 complex:
MAML1-RBP-Jkappa-Notch1 complex complex (MAML1-NOTCH1-RBPJ)
-
IRef Hprd Interaction:
RBPJ
—
MAML1
(in vitro)
-
IRef Hprd Interaction:
RBPJ
—
NOTCH1
(in vivo)
-
IRef Hprd Interaction:
RBPJ
—
NOTCH1
(in vitro)
-
IRef Hprd Interaction:
RBPJ
—
NOTCH1
(two hybrid)
-
IRef Hprd Interaction:
MAML1
—
NOTCH1
(in vitro)
-
IRef Intact Interaction:
Complex of NOTCH1-RBPJ-MAML1
(physical association, x-ray crystallography)
-
Reactome Reaction:
CREBBP
→
MAML3
(reaction)
-
Reactome Reaction:
NOTCH1
→
MAML1
(reaction)
-
Reactome Reaction:
NOTCH1
→
MAML2
(reaction)
-
Reactome Reaction:
CREBBP
→
RBPJ
(indirect_complex)
-
Reactome Reaction:
NOTCH1
→
EP300
(indirect_complex)
-
Reactome Reaction:
KAT2B
→
RBPJ
(reaction)
-
Reactome Reaction:
NOTCH1
→
MAML3
(reaction)
-
Reactome Reaction:
MAML1
→
RBPJ
(reaction)
-
Reactome Reaction:
CREBBP
→
SNW1
(indirect_complex)
-
Reactome Reaction:
CREBBP
→
NOTCH1
(reaction)
-
Reactome Reaction:
KAT2B
→
SNW1
(indirect_complex)
-
Reactome Reaction:
KAT2B
→
MAML2
(reaction)
-
Reactome Reaction:
NOTCH1
→
MAML2
(indirect_complex)
-
Reactome Reaction:
KAT2B
→
MAML3
(reaction)
-
Reactome Reaction:
EP300
→
MAML1
(reaction)
-
Reactome Reaction:
MAML3
→
RBPJ
(indirect_complex)
-
Reactome Reaction:
NOTCH1
→
MAML1
(indirect_complex)
-
Reactome Reaction:
CREBBP
→
SNW1
(reaction)
-
Reactome Reaction:
NOTCH1
→
KAT2B
(reaction)
-
Reactome Reaction:
MAML2
→
RBPJ
(reaction)
-
Reactome Reaction:
EP300
→
MAML2
(reaction)
-
Reactome Reaction:
NOTCH1
→
MAML3
(indirect_complex)
-
Reactome Reaction:
CREBBP
→
MAML3
(direct_complex)
-
Reactome Reaction:
CREBBP
→
MAML2
(reaction)
-
Reactome Reaction:
NOTCH1
→
KAT2B
(indirect_complex)
-
Reactome Reaction:
EP300
→
RBPJ
(reaction)
-
Reactome Reaction:
EP300
→
KAT2B
(direct_complex)
-
Reactome Reaction:
EP300
→
MAML2
(direct_complex)
-
Reactome Reaction:
CREBBP
→
KAT2B
(direct_complex)
-
Reactome Reaction:
SNW1
→
MAML1
(reaction)
-
Reactome Reaction:
MAML2
→
RBPJ
(indirect_complex)
-
Reactome Reaction:
CREBBP
→
EP300
(reaction)
-
Reactome Reaction:
EP300
→
MAML3
(direct_complex)
-
Reactome Reaction:
EP300
→
MAML1
(direct_complex)
-
Reactome Reaction:
SNW1
→
MAML3
(reaction)
-
Reactome Reaction:
SNW1
→
MAML3
(indirect_complex)
-
Reactome Reaction:
CREBBP
→
MAML1
(direct_complex)
-
Reactome Reaction:
CREBBP
→
NOTCH1
(indirect_complex)
-
Reactome Reaction:
CREBBP
→
RBPJ
(reaction)
-
Reactome Reaction:
CREBBP
→
MAML2
(direct_complex)
-
Reactome Reaction:
CREBBP
→
KAT2B
(reaction)
-
Reactome Reaction:
KAT2B
→
SNW1
(reaction)
-
Reactome Reaction:
EP300
→
RBPJ
(indirect_complex)
-
Reactome Reaction:
MAML3
→
RBPJ
(reaction)
-
Reactome Reaction:
CREBBP
→
MAML1
(reaction)
-
Reactome Reaction:
MAML1
→
RBPJ
(indirect_complex)
-
Reactome Reaction:
KAT2B
→
MAML2
(direct_complex)
-
Reactome Reaction:
SNW1
→
MAML1
(indirect_complex)
-
Reactome Reaction:
SNW1
→
MAML2
(reaction)
-
Reactome Reaction:
SNW1
→
MAML2
(indirect_complex)
-
Reactome Reaction:
EP300
→
MAML3
(reaction)
-
Reactome Reaction:
KAT2B
→
MAML1
(reaction)
-
Reactome Reaction:
EP300
→
SNW1
(indirect_complex)
-
Reactome Reaction:
KAT2B
→
RBPJ
(indirect_complex)
-
Reactome Reaction:
KAT2B
→
MAML1
(direct_complex)
-
Reactome Reaction:
EP300
→
KAT2B
(reaction)
-
Reactome Reaction:
EP300
→
SNW1
(reaction)
-
Reactome Reaction:
KAT2B
→
MAML3
(direct_complex)
-
Reactome Reaction:
NOTCH1
→
EP300
(reaction)
-
Reactome Reaction:
CREBBP
→
EP300
(direct_complex)
In total, 31 gene pairs are associated to this article in curated databases