Gene interactions and pathways from curated databases and text-mining
Cell 2006, PMID: 16530044

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Nam, Yunsun; Sliz, Piotr; Song, Luyan; Aster, Jon C; Blacklow, Stephen C

Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • MIPS CORUM MAML1-RBP-Jkappa-Notch1 complex: MAML1-RBP-Jkappa-Notch1 complex complex (MAML1-NOTCH1-RBPJ)
  • IRef Hprd Interaction: RBPJ — MAML1 (in vitro)
  • IRef Hprd Interaction: RBPJ — NOTCH1 (in vivo)
  • IRef Hprd Interaction: RBPJ — NOTCH1 (in vitro)
  • IRef Hprd Interaction: RBPJ — NOTCH1 (two hybrid)
  • IRef Hprd Interaction: MAML1 — NOTCH1 (in vitro)
  • IRef Intact Interaction: Complex of NOTCH1-RBPJ-MAML1 (physical association, x-ray crystallography)
  • Reactome Reaction: CREBBP → MAML3 (reaction)
  • Reactome Reaction: NOTCH1 → MAML1 (reaction)
  • Reactome Reaction: NOTCH1 → MAML2 (reaction)
  • Reactome Reaction: CREBBP → RBPJ (indirect_complex)
  • Reactome Reaction: NOTCH1 → EP300 (indirect_complex)
  • Reactome Reaction: KAT2B → RBPJ (reaction)
  • Reactome Reaction: NOTCH1 → MAML3 (reaction)
  • Reactome Reaction: MAML1 → RBPJ (reaction)
  • Reactome Reaction: CREBBP → SNW1 (indirect_complex)
  • Reactome Reaction: CREBBP → NOTCH1 (reaction)
  • Reactome Reaction: KAT2B → SNW1 (indirect_complex)
  • Reactome Reaction: KAT2B → MAML2 (reaction)
  • Reactome Reaction: NOTCH1 → MAML2 (indirect_complex)
  • Reactome Reaction: KAT2B → MAML3 (reaction)
  • Reactome Reaction: EP300 → MAML1 (reaction)
  • Reactome Reaction: MAML3 → RBPJ (indirect_complex)
  • Reactome Reaction: NOTCH1 → MAML1 (indirect_complex)
  • Reactome Reaction: CREBBP → SNW1 (reaction)
  • Reactome Reaction: NOTCH1 → KAT2B (reaction)
  • Reactome Reaction: MAML2 → RBPJ (reaction)
  • Reactome Reaction: EP300 → MAML2 (reaction)
  • Reactome Reaction: NOTCH1 → MAML3 (indirect_complex)
  • Reactome Reaction: CREBBP → MAML3 (direct_complex)
  • Reactome Reaction: CREBBP → MAML2 (reaction)
  • Reactome Reaction: NOTCH1 → KAT2B (indirect_complex)
  • Reactome Reaction: EP300 → RBPJ (reaction)
  • Reactome Reaction: EP300 → KAT2B (direct_complex)
  • Reactome Reaction: EP300 → MAML2 (direct_complex)
  • Reactome Reaction: CREBBP → KAT2B (direct_complex)
  • Reactome Reaction: SNW1 → MAML1 (reaction)
  • Reactome Reaction: MAML2 → RBPJ (indirect_complex)
  • Reactome Reaction: CREBBP → EP300 (reaction)
  • Reactome Reaction: EP300 → MAML3 (direct_complex)
  • Reactome Reaction: EP300 → MAML1 (direct_complex)
  • Reactome Reaction: SNW1 → MAML3 (reaction)
  • Reactome Reaction: SNW1 → MAML3 (indirect_complex)
  • Reactome Reaction: CREBBP → MAML1 (direct_complex)
  • Reactome Reaction: CREBBP → NOTCH1 (indirect_complex)
  • Reactome Reaction: CREBBP → RBPJ (reaction)
  • Reactome Reaction: CREBBP → MAML2 (direct_complex)
  • Reactome Reaction: CREBBP → KAT2B (reaction)
  • Reactome Reaction: KAT2B → SNW1 (reaction)
  • Reactome Reaction: EP300 → RBPJ (indirect_complex)
  • Reactome Reaction: MAML3 → RBPJ (reaction)
  • Reactome Reaction: CREBBP → MAML1 (reaction)
  • Reactome Reaction: MAML1 → RBPJ (indirect_complex)
  • Reactome Reaction: KAT2B → MAML2 (direct_complex)
  • Reactome Reaction: SNW1 → MAML1 (indirect_complex)
  • Reactome Reaction: SNW1 → MAML2 (reaction)
  • Reactome Reaction: SNW1 → MAML2 (indirect_complex)
  • Reactome Reaction: EP300 → MAML3 (reaction)
  • Reactome Reaction: KAT2B → MAML1 (reaction)
  • Reactome Reaction: EP300 → SNW1 (indirect_complex)
  • Reactome Reaction: KAT2B → RBPJ (indirect_complex)
  • Reactome Reaction: KAT2B → MAML1 (direct_complex)
  • Reactome Reaction: EP300 → KAT2B (reaction)
  • Reactome Reaction: EP300 → SNW1 (reaction)
  • Reactome Reaction: KAT2B → MAML3 (direct_complex)
  • Reactome Reaction: NOTCH1 → EP300 (reaction)
  • Reactome Reaction: CREBBP → EP300 (direct_complex)
In total, 31 gene pairs are associated to this article in curated databases