Gene interactions and pathways from curated databases and text-mining
Anesth Analg 2006, PMID: 16790644

Hydroxyethyl starch exhibits antiinflammatory effects in the intestines of endotoxemic rats.

Lv, Ran; Zhou, Zhi-Qiang; Wu, Hai-Wei; Jin, Yi; Zhou, Wei; Xu, Jian-Guo

We performed the present in vivo study to investigate the effect of hydroxyethyl starch (HES) on intestinal production of inflammatory mediators and activation of transcription factors during endotoxemia. Rats with endotoxemia induced by lipopolysaccharide (LPS) (5 mg/kg, IV) were treated with HES (16 mL/kg, IV) or saline (64 mL/kg, IV). At 2, 3, or 6 h after the LPS challenge, the rat ileal tissues were collected. Various ileal inflammatory mediator levels (tumor necrosis factor-alpha, interleukin [IL]-6, cytokine-induced neutrophil chemoattractant-1, and IL-10), inflammatory mediator messenger RNAs (mRNAs), activities of nuclear factor (NF)-kappaB and activator protein (AP)-1, and ileal myeloperoxidase-positive cells were determined in each group. HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6, cytokine-induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats. Similarly, HES could decrease the myeloperoxidase-positive cells induced by LPS and also inhibit ileal NF-kappaB and AP-1 activations. Our results suggest that during endotoxemia HES may down-regulate intestinal inflammatory mediator production, and this antiinflammatory effect of HES may act through suppression of NF-kappaB and AP-1 activations.

Diseases/Pathways annotated by Medline MESH: Endotoxemia
Document information provided by NCBI PubMed

Text Mining Data

tumor necrosis factor-alpha ⊣ HES: " HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha , IL-6, cytokine induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats "

IL-6 ⊣ HES: " HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6 , cytokine induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats "

Manually curated Databases

No curated data.