Gene interactions and pathways from curated databases and text-mining
Biomed Pharmacother 2007, PMID: 17418999

Synthesis and anti-inflammatory effect of lipoxins in human airway epithelial cells.

Bonnans, Caroline; Gras, Delphine; Chavis, Claude; Mainprice, Brigitte; Vachier, Isabelle; Godard, Philippe; Chanez, Pascal

In this study, we investigated the synthesis of lipoxins (LXs) and their anti-inflammatory effects in different human airway epithelial cell culture models. After cell incubation with exogenous 5(S),6(R)-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid, LXA(4) was detected in supernatants of differentiated human bronchial epithelial cells by contrast to non-differentiated cells. Exogenous LXA(4) significantly inhibited tumor necrosis factor-alpha (TNF-alpha)-induced interleukin-8 (IL-8) release in the different epithelial cell types and the potency of inhibition was dependent of the accessibility of the specific LXA(4) receptor, formyl-peptide receptor like-1 (FPRL-1) expressed by all these cells. Immunohistochemistry analysis on human bronchial biopsies showed a high expression of FPRL-1 in the epithelium. Finally, an FPRL-1 receptor antagonist, boc-2 peptide reversed LXA(4) effect on IL-8 generation. Together, these findings indicate that differentiated human bronchial epithelium synthesizes LX in vivo which could have autocrine actions through its specific receptor FPRL-1 to promote resolution of airway inflammation.

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Text Mining Data

interleukin-8 (IL-8) → tumor necrosis factor-alpha (TNF-alpha): " Exogenous LXA ( 4 ) significantly inhibited tumor necrosis factor-alpha (TNF-alpha) induced interleukin-8 (IL-8) release in the different epithelial cell types and the potency of inhibition was dependent of the accessibility of the specific LXA(4) receptor, formyl-peptide receptor like-1 (FPRL-1) expressed by all these cells "

Manually curated Databases

No curated data.