Gene interactions and pathways from curated databases and text-mining
Cancer Cell 2007, PMID: 17785205

LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.

Wang, Jialiang; An, Hanbing; Mayo, Marty W; Baldwin, Albert S; Yarbrough, Wendell G

LZAP has been reported to inhibit cellular proliferation and clonogenic growth. Here, we report that decreased LZAP expression promoted cellular transformation, xenograft tumor growth, and xenograft tumor vascularity. Loss of LZAP also increased cellular invasion, and MMP-9 expression dependent on NF-kappaB. LZAP directly bound to RelA, impaired serine 536 phosphorylation of RelA, increased HDAC association with RelA, inhibited basal and stimulated NF-kappaB transcriptional activity, and was found at the promoter of selective NF-kappaB-responsive genes. LZAP protein levels were markedly decreased in 32% of primary HNSCCs (n = 28) and decreased LZAP levels in primary HNSCC correlated with increased expression of the NF-kappaB-regulated genes IL-8 and IkappaBalpha. In aggregate, these data support a role of LZAP in NF-kappaB regulation and tumor suppression.

Diseases/Pathways annotated by Medline MESH: Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Head and Neck Neoplasms, Neoplasm Invasiveness
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Text Mining Data

NF-kappaB ⊣ RelA: " LZAP directly bound to RelA, impaired serine 536 phosphorylation of RelA, increased HDAC association with RelA , inhibited basal and stimulated NF-kappaB transcriptional activity, and was found at the promoter of selective NF-kappaB-responsive genes "

Manually curated Databases

  • IRef Intact Interaction: CDK5RAP3 — RELA (physical association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: CDK5RAP3 — RELA (physical association, pull down)
In total, 1 gene pairs are associated to this article in curated databases