Gene interactions and pathways from curated databases and text-mining
Biochem Biophys Res Commun 2007, PMID: 17927961

Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.

Park, Eui-Soon; Choi, Seunga; Kim, Jin-Man; Jeong, Yongsu; Choe, Joonho; Park, Chang-Sik; Choi, Yongwon; Rho, Jaerang

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are key adaptor molecules in the TNFR-signaling complexes that promote a wide variety of signaling cascades including cell proliferation, activation, differentiation, and apoptosis. TRAF-interacting protein (TRIP) is required for the inhibitory regulation of TNF-induced NF-kappaB signaling via the TNFR/TRAF-signaling complexes in vitro. TRIP also directly interacts with the familial cylindromatosis tumor suppressor gene (CYLD) and negatively regulates NF-kappaB activation in vitro. However, although there appears to be a relationship between TRIP, the TRAFs and also CYLD as modulators of NF-kappaB signaling in vitro, the functional role of TRIP in vivo is still unclear. To identify the role of TRIP in vivo, we have generated TRIP-deficient mice. Homozygous mouse embryos were found to die shortly after implantation due to proliferation defects and excessive cell death. These results indicate that TRIP is an essential factor during early mouse embryonic development in vivo.

Diseases/Pathways annotated by Medline MESH: Embryo Loss
Document information provided by NCBI PubMed

Text Mining Data

NF-kappaB ⊣ TRAF interacting protein (TRIP): " TRAF interacting protein (TRIP) is required for the inhibitory regulation of TNF induced NF-kappaB signaling via the TNFR/TRAF signaling complexes in vitro "

NF-kappaB → TNF: " TRAF interacting protein (TRIP) is required for the inhibitory regulation of TNF induced NF-kappaB signaling via the TNFR/TRAF signaling complexes in vitro "

NF-kappaB → TRIP: " TRIP also directly interacts with the familial cylindromatosis tumor suppressor gene ( CYLD ) and negatively regulates NF-kappaB activation in vitro "

Manually curated Databases

No curated data.