Gene interactions and pathways from curated databases and text-mining
Toxicol Lett 2009, PMID: 19022365

Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells.

Meng, Dan; Lv, Dan-Dan; Zhuang, Xuliang; Sun, Heng; Fan, Li; Shi, Xiang-Lin; Fang, Jing

Benzo[a]pyrene (B[a]P) has been shown to accelerate atherosclerosis development in animal models. However, the mechanisms that B[a]P induces atherogenesis are unclear. Abnormal migration and invasion of vascular smooth muscle cells (VSMCs) is a major contributor to the development of atherosclerotic lesions. In this article, we demonstrated that B[a]P promoted the migration and invasion of rat VSMCs. B[a]P increased the mRNA levels of matrix metalloproteinase (MMP) 1, 2, 3, and 9. The MMPs inhibitor GM6001 inhibited B[a]P-induced invasion of VSMCs. Among the MMPs mentioned above, MMP-3 had the maximal induction. Mechanistic studies indicate that B[a]P-induced transcriptional activation of MMP-3 is not mediated by AP-1, NF-kappaB. B[a]P-induced expression of MMPs was attenuated by alpha-naphthoflavone, the aryl hydrocarbon receptor antagonist. In addition, alpha-naphthoflavone inhibited B[a]P-induced migration and invasion of VSMCs. These results suggest that the aryl hydrocarbon receptor plays an important role in B[a]P-induced expression of MMPs and migration and invasion of VSMC. Our findings may reveal a novel role of B[a]P in inducing atherogenesis.

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Text Mining Data

AP-1 → NF-kappaB: " Mechanistic studies indicate that B [ a ] P-induced transcriptional activation of MMP-3 is not mediated by AP-1 , NF-kappaB "

MMP-3 → AP-1: " Mechanistic studies indicate that B [ a ] P-induced transcriptional activation of MMP-3 is not mediated by AP-1 , NF-kappaB "

MMP-3 → NF-kappaB: " Mechanistic studies indicate that B [ a ] P-induced transcriptional activation of MMP-3 is not mediated by AP-1, NF-kappaB "

Manually curated Databases

No curated data.